PDB
7UM6
Resolution
2.8 Å
Released
July 20, 2022
Receptor
5-HT5A
Class
A
Species
Homo sapiens
Ligand
lisuride
Function
Agonist (partial)
Reference
10.1038/S41594-022-00796-6

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Ligand Amino Acid Generic Number Segment Interaction Type
lisuride W117 3.28x28 TM3 hydrophobic
lisuride D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
lisuride V122 3.33x33 TM3 hydrophobic
lisuride V122 3.33x33 TM3 Van der Waals
lisuride C125 3.36x36 TM3 hydrophobic
lisuride C125 3.36x36 TM3 Van der Waals
lisuride S204 5.42x43 TM5 Van der Waals
lisuride F301 6.51x51 TM6 hydrophobic
lisuride F301 6.51x51 TM6 Van der Waals
lisuride F302 6.52x52 TM6 aromatic (edge-to-face)

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Snake plot — Download: PNG | SVG
ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
Helix box plot — Download: PNG | SVG L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7

GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 C125
TM5
5x43 5.42x43 S204
TM6
6x51 6.51x51 F301
6x52 6.52x52 F302