PDB
7V68
Resolution
3.4 Å
Released
May 11, 2022
Receptor
M4
Class
A
Species
Homo sapiens
Ligands
LY2119620
iperoxo
Function
PAM
Agonist
Reference
10.1038/S41467-022-30595-Y
LY2119620 iperoxo

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
LY2119620 Y92 2.64x63 TM2 hydrophobic
iperoxo Y113 3.33x33 TM3 hydrophobic
LY2119620 F186 45.51x51 ECL2 aromatic (face-to-face)
LY2119620 L190 ECL2 hydrophobic
iperoxo A203 5.46x461 TM5 Van der Waals
iperoxo A203 5.46x461 TM5 polar (hydrogen bond with backbone)
iperoxo F204 5.47x47 TM5 Van der Waals
iperoxo W413 6.48x48 TM6 Van der Waals
iperoxo W413 6.48x48 TM6 hydrophobic
iperoxo Y416 6.51x51 TM6 Van der Waals
iperoxo Y416 6.51x51 TM6 hydrophobic
LY2119620 C426 ECL3 Van der Waals
LY2119620 Q427 ECL3 polar (hydrogen bond)
LY2119620 Q427 ECL3 Van der Waals
LY2119620 D432 7.32x31 TM7 Van der Waals
LY2119620 D432 7.32x31 TM7 polar (hydrogen bond with backbone)
LY2119620 T433 7.33x32 TM7 Van der Waals
LY2119620 W435 7.35x34 TM7 Van der Waals
LY2119620 W435 7.35x34 TM7 hydrophobic
LY2119620 S436 7.36x35 TM7 Van der Waals
LY2119620 Y439 7.39x38 TM7 polar (hydrogen bond)
iperoxo Y439 7.39x38 TM7 hydrophobic
iperoxo Y439 7.39x38 TM7 Van der Waals
iperoxo C442 7.42x41 TM7 Van der Waals
iperoxo Y443 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
Helix box plot — Download: PNG | SVG I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7

GPCRdb(A)
GPCRdb(A)
M4 receptor
TM2
2x63 2.64x63 Y92
TM3
3x33 3.33x33 Y113
ECL2
45x51 45.51x51 F186
TM5
5x461 5.46x461 A203
5x47 5.47x47 F204
TM6
6x48 6.48x48 W413
6x51 6.51x51 Y416
TM7
7x31 7.32x31 D432
7x32 7.33x32 T433
7x34 7.35x34 W435
7x35 7.36x35 S436
7x38 7.39x38 Y439
7x41 7.42x41 C442
7x42 7.43x42 Y443