PDB
7V6A
Resolution
3.6 Å
Released
May 11, 2022
Receptor
M4
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL6164470
Allosteric agonist
Reference
10.1038/S41467-022-30595-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL6164470 Y92 2.64x63 TM2 Van der Waals
CHEMBL6164470 F186 45.51x51 ECL2 hydrophobic
CHEMBL6164470 Y416 6.51x51 TM6 hydrophobic
CHEMBL6164470 M419 6.54x54 TM6 hydrophobic
CHEMBL6164470 V420 6.55x55 TM6 hydrophobic
CHEMBL6164470 N423 6.58x58 TM6 Van der Waals
CHEMBL6164470 Q427 ECL3 Van der Waals
CHEMBL6164470 S428 ECL3 Van der Waals
CHEMBL6164470 C429 ECL3 Van der Waals
CHEMBL6164470 I430 ECL3 Van der Waals
CHEMBL6164470 P431 7.31x30 TM7 Van der Waals
CHEMBL6164470 D432 7.32x31 TM7 polar (charge-charge)
CHEMBL6164470 W435 7.35x34 TM7 hydrophobic
CHEMBL6164470 S436 7.36x35 TM7 Van der Waals
CHEMBL6164470 Y439 7.39x38 TM7 Van der Waals

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ICL1 R Q L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P A R R ICL2ECL2 K R T V P D N Q C F I Q F L S ECL2ICL3 G P K E K K A K T L A F L K S P L M K Q S V K K P P P G E A A R E E L R N G K L E E A P P P A L P P P P R P V A D K D T S N E S S S G S A T Q N T K E R P A T E L S T T E A T T P A M P A P P L Q P R A L N P A S R W S K I Q I V T K Q T G N E C V T A I E I V P A T P A G M R P A A N V A R K F A S I A R N Q V R K K ICL3ECL3 Q S C I ECL3N-term M A N F T P V N G S S G N Q S V R L V T S S S H N N-termC-term Y R N I G T A R C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
Helix box plot — Download: PNG | SVG I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7

GPCRdb(A)
GPCRdb(A)
M4 receptor
TM2
2x63 2.64x63 Y92
ECL2
45x51 45.51x51 F186
TM6
6x51 6.51x51 Y416
6x54 6.54x54 M419
6x55 6.55x55 V420
6x58 6.58x58 N423
TM7
7x30 7.31x30 P431
7x31 7.32x31 D432
7x34 7.35x34 W435
7x35 7.36x35 S436
7x38 7.39x38 Y439