PDB
7V9M
Resolution
3.3 Å
Released
Oct. 20, 2021
Receptor
GHRH
Class
B1
Species
Homo sapiens
Ligand
Function
GHRH (Human)
Agonist
Reference
10.1073/PNAS.2106606118

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Ligand Amino Acid Generic Number Segment Interaction Type
GHRH (Human) L55 1.29x29 TM1 polar (hydrogen bond with backbone)
GHRH (Human) E58 1.32x32 TM1 hydrophobic
GHRH (Human) E59 1.33x33 TM1 Van der Waals
GHRH (Human) F62 1.36x36 TM1 hydrophobic
GHRH (Human) F62 1.36x36 TM1 aromatic (edge-to-face)
GHRH (Human) V65 1.39x39 TM1 hydrophobic
GHRH (Human) K66 1.40x40 TM1 hydrophobic
GHRH (Human) Y69 1.43x43 TM1 polar (hydrogen bond)
GHRH (Human) V115 2.64x64 TM2 Van der Waals
GHRH (Human) K118 2.67x67 TM2 polar (charge-charge)
GHRH (Human) K118 2.67x67 TM2 hydrophobic
GHRH (Human) K118 2.67x67 TM2 polar (hydrogen bond)
GHRH (Human) L122 2.71x71 TM2 Van der Waals
GHRH (Human) H124 ECL1 polar (hydrogen bond)
GHRH (Human) D129 ECL1 polar (hydrogen bond)
GHRH (Human) H130 ECL1 aromatic (pi-cation)
GHRH (Human) C131 ECL1 Van der Waals
GHRH (Human) C138 3.29x29 TM3 Van der Waals
GHRH (Human) S145 3.36x36 TM3 polar (hydrogen bond)
GHRH (Human) H146 3.37x37 TM3 polar (hydrogen bond)
GHRH (Human) T149 3.40x40 TM3 hydrophobic
GHRH (Human) D210 45.52x52 ECL2 polar (hydrogen bond)
GHRH (Human) D210 45.52x52 ECL2 polar (charge-charge)
GHRH (Human) L211 ECL2 Van der Waals
GHRH (Human) D212 ECL2 Van der Waals
GHRH (Human) D213 ECL2 Van der Waals
GHRH (Human) W218 5.36x37 TM5 hydrophobic
GHRH (Human) I221 5.39x39 TM5 Van der Waals
GHRH (Human) I225 5.43x43 TM5 hydrophobic
GHRH (Human) D286 ECL3 polar (charge-charge)
GHRH (Human) L290 7.35x34 TM7 hydrophobic
GHRH (Human) R293 7.38x37 TM7 Van der Waals
GHRH (Human) L294 7.39x38 TM7 hydrophobic
GHRH (Human) E297 7.42x41 TM7 hydrophobic
GHRH (Human) L298 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 H S D D T D H C S F S ECL1ICL2 T S P S S ICL2ECL2 D I A C W D L D D T S P Y ECL2ICL3 E P A Q G S L ICL3ECL3 P D N A ECL3N-term M D R R M W G A H V F C V L S P L P T V L G H M H P E C D F I T Q L R E D E S A C L Q A A E E M P N T T L G C P A T W D G L L C W P T A G S G E W V T L P C P D F F S H F S S E S G A V K R D C T I T G W S E P F P P Y P V A C P V P N-termC-term A K W T T P S R S A A K V L T S M C C-term L E L L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L H T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E I S R H D P A W R V R T E K W H G E L L P T R
Helix box plot — Download: PNG | SVG F L A V I S I S H G V T Y I I K V T S F 1 T Q L F T T F I L K A G A V F L K D A A 2 A L L W S F N T M T A F H S A A V S V K 3 A F W W L V L G A W G L P V L F T G T W V 4 F L G F N V G V S L V I P G K I I W W 5 L F L I P L F G I H Y I I F N F L 6 I A V I F G Q F S G L G L E L P L R I 7

GPCRdb(A)
GPCRdb(B)
GHRH receptor
TM1
1x25 1.29x29 L119
1x28 1.32x32 E122
1x29 1.33x33 E123
1x32 1.36x36 F126
1x35 1.39x39 V129
1x36 1.40x40 K130
1x39 1.43x43 Y133
TM2
2x57 2.64x64 V179
2x60 2.67x67 K182
2x64 2.71x71 L186
TM3
3x25 3.29x29 C202
3x32 3.36x36 S209
3x33 3.37x37 H210
3x36 3.40x40 T213
ECL2
45x52 45.52x52 D274
TM5
5x41 5.36x37 W282
5x43 5.39x39 I285
5x47 5.43x43 I289
TM7
7x30 7.35x34 L354
7x33 7.38x37 R357
7x34 7.39x38 L358
7x37 7.42x41 E361
7x38 7.43x42 L362