PDB
7VBI
Resolution
3.0 Å
Released
March 2, 2022
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Non-acylated tirzepatide
Function
Agonist
Reference
10.1038/S41467-022-28683-0

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Non-acylated tirzepatide V30 N-term polar (hydrogen bond with backbone)
Non-acylated tirzepatide V30 N-term Van der Waals
Non-acylated tirzepatide S31 N-term Van der Waals
Non-acylated tirzepatide S31 N-term polar (hydrogen bond with backbone)
Non-acylated tirzepatide L32 N-term polar (hydrogen bond with backbone)
Non-acylated tirzepatide L32 N-term Van der Waals
Non-acylated tirzepatide T35 N-term Van der Waals
Non-acylated tirzepatide W39 N-term hydrophobic
Non-acylated tirzepatide W39 N-term Van der Waals
Non-acylated tirzepatide E68 N-term Van der Waals
Non-acylated tirzepatide Y69 N-term Van der Waals
Non-acylated tirzepatide Y69 N-term hydrophobic
Non-acylated tirzepatide Y88 N-term hydrophobic
Non-acylated tirzepatide Y88 N-term Van der Waals
Non-acylated tirzepatide P90 N-term hydrophobic
Non-acylated tirzepatide P90 N-term Van der Waals
Non-acylated tirzepatide W91 N-term Van der Waals
Non-acylated tirzepatide W91 N-term hydrophobic
Non-acylated tirzepatide R121 N-term polar (charge-assisted hydrogen bond)
Non-acylated tirzepatide L123 N-term Van der Waals
Non-acylated tirzepatide E127 N-term polar (charge-assisted hydrogen bond)
Non-acylated tirzepatide L141 1.36x36 TM1 hydrophobic
Non-acylated tirzepatide L141 1.36x36 TM1 Van der Waals
Non-acylated tirzepatide L144 1.39x39 TM1 hydrophobic
Non-acylated tirzepatide Y145 1.40x40 TM1 Van der Waals
Non-acylated tirzepatide Y145 1.40x40 TM1 hydrophobic
Non-acylated tirzepatide Y148 1.43x43 TM1 Van der Waals
Non-acylated tirzepatide Y148 1.43x43 TM1 aromatic (edge-to-face)
Non-acylated tirzepatide Y152 1.47x47 TM1 polar (hydrogen bond)
Non-acylated tirzepatide R190 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Non-acylated tirzepatide K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Non-acylated tirzepatide L201 2.71x71 TM2 Van der Waals
Non-acylated tirzepatide L201 2.71x71 TM2 hydrophobic
Non-acylated tirzepatide Y205 2.75x75 TM2 polar (hydrogen bond)
Non-acylated tirzepatide Q210 ECL1 Van der Waals
Non-acylated tirzepatide W214 ECL1 hydrophobic
Non-acylated tirzepatide W214 ECL1 Van der Waals
Non-acylated tirzepatide M233 3.36x36 TM3 Van der Waals
Non-acylated tirzepatide Q234 3.37x37 TM3 polar (hydrogen bond)
Non-acylated tirzepatide Q234 3.37x37 TM3 polar (hydrogen bond)
Non-acylated tirzepatide V237 3.40x40 TM3 Van der Waals
Non-acylated tirzepatide V237 3.40x40 TM3 hydrophobic
Non-acylated tirzepatide T298 45.52x52 ECL2 polar (hydrogen bond)
Non-acylated tirzepatide R299 ECL2 Van der Waals
Non-acylated tirzepatide N300 ECL2 Van der Waals
Non-acylated tirzepatide W306 5.36x37 TM5 hydrophobic
Non-acylated tirzepatide W306 5.36x37 TM5 Van der Waals
Non-acylated tirzepatide I309 5.39x39 TM5 Van der Waals
Non-acylated tirzepatide D372 ECL3 polar (charge-assisted hydrogen bond)
Non-acylated tirzepatide R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Non-acylated tirzepatide L384 7.39x38 TM7 Van der Waals
Non-acylated tirzepatide L384 7.39x38 TM7 hydrophobic
Non-acylated tirzepatide E387 7.42x41 TM7 Van der Waals
Non-acylated tirzepatide L388 7.43x42 TM7 Van der Waals
Non-acylated tirzepatide L388 7.43x42 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x32 3.36x36 M233
3x33 3.37x37 Q234
3x36 3.40x40 V237
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x43 5.39x39 I309
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388