Structure information

MRGPRX2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VDL

SPECIES

Homo sapiens

RESOLUTION

3.220

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-04077-Y

PUBLICATION DATE

Dec. 1, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cortistatin 14 M109 3.32x32 TM3 hydrophobic
Cortistatin 14 F170 ECL2 hydrophobic
Cortistatin 14 W243 6.55x55 TM6 polar (hydrogen bond with backbone)
Cortistatin 14 W243 6.55x55 TM6 Van der Waals
Cortistatin 14 W248 6.60x60 TM6 Van der Waals
Cortistatin 14 H261 7.35x34 TM7 Van der Waals
Cortistatin 14 H261 7.35x34 TM7 aromatic (face-to-edge)

Ligands

Cortistatin 14

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Residue Diagrams

G N G V L G V L A I F L I L F V P I L T 1 L S L A G A D F L F L C F Q I I N C L V 2 T S L M S L G A L Y A C T M V T T F F S 3 S A V V C V L L W A L S L L L S I L E G 4 S S G C L V M F L F I L W A A T I F D F 5 L L T V L V F L L C G L P F G I Q W F L 6 I P N A S S N L S S L V V S V P H I H 7
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ICL1 R R ICL1ECL1 I S I N F ECL1ICL2 P I W Y R C R R ICL2ECL2 G F L F S D G ECL2ICL3 S R G L ICL3ECL3 K D S D V ECL3N-term M D P T T P A W G T E S T T V N G N D Q A L L L L C G K E N-termC-term R K Q W R L Q Q P I L K L A L Q R A L Q D I A E V D H S E G C F R Q G T P E M S R S S L V C-term T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P R H L S A V V C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX2
TM3
3x32 3.32x32 M109
TM6
6x55 6.55x55 W243
6x60 6.60x60 W248
TM7
7x34 7.35x34 H261