PDB
7VFX
Resolution
2.8 Å
Released
Sept. 21, 2022
Receptor
FPR1
Class
A
Species
Homo sapiens
Ligand
Function
fMIFL
Agonist
Reference
10.1038/S41467-022-32822-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
fMIFL F81 2.60x60 TM2 hydrophobic
fMIFL R84 2.63x63 TM2 polar (charge-charge)
fMIFL F102 3.29x29 TM3 hydrophobic
fMIFL D106 3.33x33 TM3 polar (hydrogen bond)
fMIFL L109 3.36x36 TM3 hydrophobic
fMIFL F110 3.37x37 TM3 hydrophobic
fMIFL V113 3.40x40 TM3 hydrophobic
fMIFL V164 ECL2 Van der Waals
fMIFL C176 45.50x50 ECL2 Van der Waals
fMIFL T177 45.51x51 ECL2 Van der Waals
fMIFL F178 45.52x52 ECL2 hydrophobic
fMIFL R201 5.38x39 TM5 polar (hydrogen bond)
fMIFL R205 5.42x43 TM5 hydrophobic
fMIFL R205 5.42x43 TM5 polar (hydrogen bond)
fMIFL G209 5.46x461 TM5 Van der Waals
fMIFL W254 6.48x48 TM6 Van der Waals
fMIFL Y257 6.51x51 TM6 polar (hydrogen bond)
fMIFL A264 6.58x58 TM6 hydrophobic
fMIFL I268 ECL3 hydrophobic
fMIFL V283 7.35x34 TM7 hydrophobic
fMIFL F291 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T H ICL1ECL1 G H W P F ECL1ICL2 P V W T Q N H R ICL2ECL2 T T V P G K T G T V A C T F N F S P W T N ECL2ICL3 L I K S ICL3ECL3 I R E L L Q G M ECL3N-term M E T N S S L P T N I S G G T P A V N-termC-term P A S L E R A L T E D S T Q T S D T A T N S T L P S A E V E L Q A K C-term S A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H T V S L A K K V I I G P W V M A L L L T L P V I I R V D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D L I H F R E R A L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V A F V L Y T I I D 1 L N L A V A D F C F T S T L P F F M V R 2 L A I L F V S G F L N I D V I T F V F K 3 A K K V I I G P W V M A L L L T L P V 4 Y S V A V I S M P A S F G I I F R I I G R 5 S F V A A A F F L C W S P Y Q V V A L I 6 M P N L C S N F F A L A S T V D V A I 7

GPCRdb(A)
GPCRdb(A)
FPR1
TM2
2x60 2.60x60 F81
2x63 2.63x63 R84
TM3
3x29 3.29x29 F102
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x50 45.50x50 C176
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 Y257
6x58 6.58x58 A264
TM7
7x34 7.35x34 V283
7x42 7.43x42 F291