PDB
7VGZ
Resolution
3.3 Å
Released
March 2, 2022
Receptor
MT1
Class
A
Species
Homo sapiens
Ligand
Function
ramelteon
Agonist
Reference
10.1038/S41467-022-28111-3

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Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon G104 3.29x29 TM3 Van der Waals
ramelteon M107 3.32x32 TM3 Van der Waals
ramelteon G108 3.33x33 TM3 Van der Waals
ramelteon V111 3.36x36 TM3 hydrophobic
ramelteon I112 3.37x37 TM3 hydrophobic
ramelteon N162 4.60x61 TM4 Van der Waals
ramelteon T178 45.51x51 ECL2 Van der Waals
ramelteon F179 45.52x52 ECL2 hydrophobic
ramelteon Q181 ECL2 Van der Waals
ramelteon Y187 5.38x39 TM5 Van der Waals
ramelteon T188 5.39x40 TM5 hydrophobic
ramelteon V191 5.42x43 TM5 hydrophobic
ramelteon V192 5.43x44 TM5 hydrophobic
ramelteon H195 5.46x461 TM5 Van der Waals
ramelteon L254 6.51x51 TM6 Van der Waals
ramelteon N255 6.52x52 TM6 Van der Waals
ramelteon G258 6.55x55 TM6 Van der Waals
ramelteon Y281 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
Helix box plot — Download: PNG | SVG L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7

GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x29 3.29x29 G104
3x32 3.32x32 M107
3x33 3.33x33 G108
3x36 3.36x36 V111
3x37 3.37x37 I112
TM4
4x61 4.60x61 N162
ECL2
45x51 45.51x51 T178
45x52 45.52x52 F179
TM5
5x39 5.38x39 Y187
5x40 5.39x40 T188
5x43 5.42x43 V191
5x44 5.43x44 V192
5x461 5.46x461 H195
TM6
6x51 6.51x51 L254
6x52 6.52x52 N255
6x55 6.55x55 G258
TM7
7x38 7.39x38 Y281