PDB
7VH0
Resolution
3.5 Å
Released
March 2, 2022
Receptor
MT2
Class
A
Species
Homo sapiens
Ligand
Function
ramelteon
Agonist
Reference
10.1038/S41467-022-28111-3

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Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon A117 3.29x29 TM3 Van der Waals
ramelteon M120 3.32x32 TM3 hydrophobic
ramelteon G121 3.33x33 TM3 Van der Waals
ramelteon I125 3.37x37 TM3 hydrophobic
ramelteon L172 4.57x57 TM4 Van der Waals
ramelteon N175 4.60x61 TM4 Van der Waals
ramelteon T191 45.51x51 ECL2 Van der Waals
ramelteon F192 45.52x52 ECL2 hydrophobic
ramelteon V204 5.42x43 TM5 hydrophobic
ramelteon V205 5.43x44 TM5 hydrophobic
ramelteon W264 6.48x48 TM6 Van der Waals
ramelteon L267 6.51x51 TM6 Van der Waals
ramelteon N268 6.52x52 TM6 Van der Waals
ramelteon G271 6.55x55 TM6 Van der Waals

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ICL1 R K L R ICL1ECL1 G W A L ECL1ICL2 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A P Q I ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P N-termC-term P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R L W N F R R E I L L A
Helix box plot — Download: PNG | SVG L N G V V D V A T T V I L V A S L A P A 1 V S L A L A D L V V A Y F P Y P L I L V A 2 A T I N F V S G I V S L G M V F A S A K 3 T P L H I C L I W L L T V V A L L P N 4 Y C F S V V A I P L L F H I V V V A A T Y 5 F V V F V I F A I C W A P L N C I G L A 6 I A N L C S N F Y A L L Y S T V F L G 7

GPCRdb(A)
GPCRdb(A)
MT2 receptor
TM3
3x29 3.29x29 A117
3x32 3.32x32 M120
3x33 3.33x33 G121
3x37 3.37x37 I125
TM4
4x57 4.57x57 L172
4x61 4.60x61 N175
ECL2
45x51 45.51x51 T191
45x52 45.52x52 F192
TM5
5x43 5.42x43 V204
5x44 5.43x44 V205
TM6
6x48 6.48x48 W264
6x51 6.51x51 L267
6x52 6.52x52 N268
6x55 6.55x55 G271