PDB
7VKT
Resolution
2.9 Å
Released
March 9, 2022
Receptor
BLT1
Class
A
Species
Homo sapiens
Ligand
LTB4
Function
Agonist
Reference
10.1038/S41467-022-28820-9

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Ligand Amino Acid Generic Number Segment Interaction Type
LTB4 F74 2.60x60 TM2 hydrophobic
LTB4 L78 2.64x64 TM2 hydrophobic
LTB4 M101 3.36x36 TM3 hydrophobic
LTB4 Y102 3.37x37 TM3 hydrophobic
LTB4 W234 6.48x48 TM6 hydrophobic
LTB4 N268 7.36x35 TM7 polar (hydrogen bond)
LTB4 N268 7.36x35 TM7 Van der Waals
LTB4 I271 7.39x38 TM7 hydrophobic
LTB4 I271 7.39x38 TM7 Van der Waals
LTB4 F275 7.43x42 TM7 Van der Waals
LTB4 F275 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M Q K R ICL1ECL1 T W S F ECL1ICL2 P F V S Q K L R ICL2ECL2 T V V P W K T N M S L C F P R Y P ECL2ICL3 R F R R ICL3ECL3 Q A A G L ECL3N-term M N T T S S A A P P S L N-termC-term G V G F V A K L L E G T G S E A S S T R R G G S L G Q T A R S G P A A L E P G P S E S L T A S S P L K L N E L N C-term G V E F I S L L A I I L L S V A L A V G L P G N S F V V W S I L K R S V T A L M V L N L A L A D L A V L L T A P F F L H F L A Q G G L A G C R L C H Y V C G V S M Y A S V L L I T A M S L D R S L A V A R T K A M A R R V L A G I W V L S F L L A T P V L A Y R S E G H R A F H L I F E A V T G F L L P F L A V V A S Y S D I G R R L Q A R S R R T G R L V V L I I L T F A A F W L P Y H V V N L A E A G R A L A G G L V G K R L S L A R N V L I A L A F L S S S V N P V L Y A C A G G G L L R S A
Helix box plot — Download: PNG | SVG S N G P L G V A L A V S L L I I A L L S 1 L N L A L A D L A V L L T A P F F L H F 2 A T I L L V S A Y M S V G C V Y H C L R 3 A R R V L A G I W V L S F L L A T P V 4 Y S A V V A L F P L L F G T V A E F I L H 5 V L I I L T F A A F W L P Y H V V N L A 6 V P N V S S S L F A L A I L V N R A L 7

GPCRdb(A)
GPCRdb(A)
BLT1 receptor
TM2
2x60 2.60x60 F74
2x64 2.64x64 L78
TM3
3x36 3.36x36 M101
3x37 3.37x37 Y102
TM6
6x48 6.48x48 W234
TM7
7x35 7.36x35 N268
7x38 7.39x38 I271
7x42 7.43x42 F275