PDB
7VKT
Resolution
2.9 Å
Released
March 9, 2022
Receptor
BLT1
Class
A
Species
Homo sapiens
Ligand
Function
LTB4
Agonist
Reference
10.1038/S41467-022-28820-9

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Ligand Amino Acid Generic Number Segment Interaction Type
LTB4 A21 1.35x35 TM1 Van der Waals
LTB4 F74 2.60x60 TM2 hydrophobic
LTB4 F77 2.63x63 TM2 Van der Waals
LTB4 L78 2.64x64 TM2 hydrophobic
LTB4 G98 3.33x33 TM3 Van der Waals
LTB4 M101 3.36x36 TM3 hydrophobic
LTB4 Y102 3.37x37 TM3 hydrophobic
LTB4 V105 3.40x40 TM3 hydrophobic
LTB4 V152 4.60x61 TM4 Van der Waals
LTB4 E185 5.42x43 TM5 hydrophobic
LTB4 G189 5.46x461 TM5 Van der Waals
LTB4 W234 6.48x48 TM6 hydrophobic
LTB4 N268 7.36x35 TM7 polar (hydrogen bond)
LTB4 I271 7.39x38 TM7 hydrophobic
LTB4 F275 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M Q K R ICL1ECL1 T W S F ECL1ICL2 P F V S Q K L R ICL2ECL2 T V V P W K T N M S L C F P R Y P ECL2ICL3 R F R R ICL3ECL3 Q A A G L ECL3N-term M N T T S S A A P P S L N-termC-term G V G F V A K L L E G T G S E A S S T R R G G S L G Q T A R S G P A A L E P G P S E S L T A S S P L K L N E L N C-term G V E F I S L L A I I L L S V A L A V G L P G N S F V V W S I L K R S V T A L M V L N L A L A D L A V L L T A P F F L H F L A Q G G L A G C R L C H Y V C G V S M Y A S V L L I T A M S L D R S L A V A R T K A M A R R V L A G I W V L S F L L A T P V L A Y R S E G H R A F H L I F E A V T G F L L P F L A V V A S Y S D I G R R L Q A R S R R T G R L V V L I I L T F A A F W L P Y H V V N L A E A G R A L A G G L V G K R L S L A R N V L I A L A F L S S S V N P V L Y A C A G G G L L R S A
Helix box plot — Download: PNG | SVG S N G P L G V A L A V S L L I I A L L S 1 L N L A L A D L A V L L T A P F F L H F 2 A T I L L V S A Y M S V G C V Y H C L R 3 A R R V L A G I W V L S F L L A T P V 4 Y S A V V A L F P L L F G T V A E F I L H 5 V L I I L T F A A F W L P Y H V V N L A 6 V P N V S S S L F A L A I L V N R A L 7

GPCRdb(A)
GPCRdb(A)
BLT1 receptor
TM1
1x35 1.35x35 A21
TM2
2x60 2.60x60 F74
2x63 2.63x63 F77
2x64 2.64x64 L78
TM3
3x33 3.33x33 G98
3x36 3.36x36 M101
3x37 3.37x37 Y102
3x40 3.40x40 V105
TM4
4x61 4.60x61 V152
TM5
5x43 5.42x43 E185
5x461 5.46x461 G189
TM6
6x48 6.48x48 W234
TM7
7x35 7.36x35 N268
7x38 7.39x38 I271
7x42 7.43x42 F275