PDB
7VUJ
Resolution
3.8 Å
Released
Dec. 29, 2021
Receptor
GPR139
Class
A
Species
Homo sapiens
Ligand
JNJ-63533054
Function
Agonist
Reference
10.1038/S41422-021-00591-W

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Ligand Amino Acid Generic Number Segment Interaction Type
JNJ-63533054 F109 3.33x33 TM3 hydrophobic
JNJ-63533054 I112 3.36x36 TM3 hydrophobic
JNJ-63533054 I169 ECL2 hydrophobic
JNJ-63533054 R244 6.51x51 TM6 polar (charge-assisted hydrogen bond)
JNJ-63533054 M247 6.54x54 TM6 Van der Waals
JNJ-63533054 I248 6.55x55 TM6 Van der Waals
JNJ-63533054 I248 6.55x55 TM6 hydrophobic
JNJ-63533054 H251 6.58x58 TM6 Van der Waals
JNJ-63533054 N271 7.39x38 TM7 polar (hydrogen bond)
JNJ-63533054 N271 7.39x38 TM7 Van der Waals
JNJ-63533054 L275 7.43x42 TM7 hydrophobic
JNJ-63533054 L275 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 Q L V A R R Q ICL1ECL1 N M Q ECL1ICL2 P L K Y H T V S ICL2ECL2 W P N I W T E D Y I S ECL2ICL3 S N F R L R ICL3ECL3 A P I Q ECL3N-term M E H T H A H L A A N S S L S W W S P G S A C G L G N-termC-term K C Q K Q P V Q F Y T N H N F S I T S S P W I S P A N S H C I K M L V Y Q Y D K N G K P I K V S P C-term F V P V V Y Y S L L L C L G L P A N I L T V I I L S K S S Y N Y L L A L A A A D I L V L F F I V F V D F L L E D F I L M P Q V P D K I I E V L E F S S I H T S I W I T V P L T I D R Y I A V C H Y P A R T R K V I V S V Y I T C F L T S I P Y Y W T S V H H V L I W I H C F T V Y L V P C S I F F I L N S I I V Y K L R R K G Y S T G K T T A I L F T I T S I F A T L W A P R I I M I L Y H L Y G N R W L V H I M S D I A N M L A L L N T A I N F F L Y C F I S K R A A A F F F R T M T L K A
Helix box plot — Download: PNG | SVG I N A P L G L C L L L S Y Y V V P V F 1 L A L A A A D I L V L F F I V F V D F L 2 P V T I W I S T H I S S F E L V E I I K 3 T R K V I V S V Y I T C F L T S I P Y 4 N L I F F I S C P V L Y V T F C H I W I L 5 F T I T S I F A T L W A P R I I M I L Y 6 F F N I A T N L L A L M N A I D S M I 7

GPCRdb(A)
GPCRdb(A)
GPR139
TM3
3x33 3.33x33 F109
3x36 3.36x36 I112
TM6
6x51 6.51x51 R244
6x54 6.54x54 M247
6x55 6.55x55 I248
6x58 6.58x58 H251
TM7
7x38 7.39x38 N271
7x42 7.43x42 L275