Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7VVK

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2022.07.003

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
teriparatide V31 N-term Van der Waals
teriparatide V31 N-term polar (hydrogen bond with backbone)
teriparatide M32 N-term Van der Waals
teriparatide M32 N-term polar (hydrogen bond with backbone)
teriparatide D113 N-term Van der Waals
teriparatide H114 N-term Van der Waals
teriparatide I115 N-term Van der Waals
teriparatide T163 N-term polar (hydrogen bond with backbone)
teriparatide T163 N-term Van der Waals
teriparatide F184 1.36x36 TM1 Van der Waals
teriparatide F184 1.36x36 TM1 hydrophobic
teriparatide L187 1.39x39 TM1 hydrophobic
teriparatide L187 1.39x39 TM1 Van der Waals
teriparatide Y195 1.47x47 TM1 Van der Waals
teriparatide Y195 1.47x47 TM1 polar (hydrogen bond)
teriparatide R233 2.60x60 TM2 Van der Waals
teriparatide K240 2.67x67 TM2 Van der Waals
teriparatide Y245 2.72x72 TM2 Van der Waals
teriparatide F288 3.36x36 TM3 hydrophobic
teriparatide F288 3.36x36 TM3 Van der Waals
teriparatide L292 3.40x40 TM3 Van der Waals
teriparatide L292 3.40x40 TM3 hydrophobic
teriparatide Y296 3.44x44 TM3 hydrophobic
teriparatide Y296 3.44x44 TM3 Van der Waals
teriparatide D353 45.52x52 ECL2 Van der Waals
teriparatide L354 ECL2 Van der Waals
teriparatide L354 ECL2 hydrophobic
teriparatide S355 ECL2 Van der Waals
teriparatide K360 5.36x37 TM5 Van der Waals
teriparatide Q364 5.40x40 TM5 Van der Waals
teriparatide I367 5.43x43 TM5 hydrophobic
teriparatide L368 5.44x44 TM5 Van der Waals
teriparatide L368 5.44x44 TM5 hydrophobic
teriparatide M425 6.57x57 TM6 Van der Waals
teriparatide M425 6.57x57 TM6 polar (hydrogen bond with backbone)
teriparatide T427 6.59x59 TM6 polar (hydrogen bond with backbone)
teriparatide T427 6.59x59 TM6 Van der Waals
teriparatide P428 ECL3 Van der Waals
teriparatide Y429 ECL3 polar (hydrogen bond)
teriparatide Y429 ECL3 Van der Waals
teriparatide T430 ECL3 Van der Waals
teriparatide W437 7.35x34 TM7 Van der Waals
teriparatide W437 7.35x34 TM7 polar (hydrogen bond)
teriparatide Q440 7.38x37 TM7 polar (hydrogen bond)
teriparatide Q440 7.38x37 TM7 Van der Waals
teriparatide M441 7.39x38 TM7 Van der Waals
teriparatide M441 7.39x38 TM7 hydrophobic
teriparatide E444 7.42x41 TM7 polar (charge-assisted hydrogen bond)
teriparatide M445 7.43x42 TM7 Van der Waals
teriparatide M445 7.43x42 TM7 hydrophobic

Ligands

teriparatide

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x32 1.36x36 F184
1x35 1.39x39 L187
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x60 2.67x67 K240
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x52 6.57x57 M425
6x54 6.59x59 T427
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445