Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7VVM

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2022.07.003

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Parathyroid hormone F184 1.36x36 TM1 aromatic (face-to-face)
Parathyroid hormone L187 1.39x39 TM1 hydrophobic
Parathyroid hormone Y195 1.47x47 TM1 polar (hydrogen bond)
Parathyroid hormone Y195 1.47x47 TM1 Van der Waals
Parathyroid hormone R233 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Parathyroid hormone F288 3.36x36 TM3 hydrophobic
Parathyroid hormone F288 3.36x36 TM3 Van der Waals
Parathyroid hormone L289 3.37x37 TM3 hydrophobic
Parathyroid hormone L289 3.37x37 TM3 Van der Waals
Parathyroid hormone L292 3.40x40 TM3 Van der Waals
Parathyroid hormone L292 3.40x40 TM3 hydrophobic
Parathyroid hormone Y296 3.44x44 TM3 Van der Waals
Parathyroid hormone D353 45.52x52 ECL2 Van der Waals
Parathyroid hormone K360 5.36x37 TM5 Van der Waals
Parathyroid hormone Q364 5.40x40 TM5 Van der Waals
Parathyroid hormone I367 5.43x43 TM5 Van der Waals
Parathyroid hormone I367 5.43x43 TM5 hydrophobic
Parathyroid hormone L368 5.44x44 TM5 Van der Waals
Parathyroid hormone L368 5.44x44 TM5 hydrophobic
Parathyroid hormone M425 ECL3 Van der Waals
Parathyroid hormone M425 ECL3 polar (hydrogen bond with backbone)
Parathyroid hormone T427 ECL3 polar (hydrogen bond with backbone)
Parathyroid hormone T427 ECL3 Van der Waals
Parathyroid hormone Y429 ECL3 Van der Waals
Parathyroid hormone T430 ECL3 polar (hydrogen bond)
Parathyroid hormone T430 ECL3 polar (hydrogen bond with backbone)
Parathyroid hormone W437 7.35x34 TM7 Van der Waals
Parathyroid hormone W437 7.35x34 TM7 polar (hydrogen bond)
Parathyroid hormone Q440 7.38x37 TM7 polar (hydrogen bond)
Parathyroid hormone Q440 7.38x37 TM7 Van der Waals
Parathyroid hormone M441 7.39x38 TM7 Van der Waals
Parathyroid hormone M441 7.39x38 TM7 hydrophobic
Parathyroid hormone E444 7.42x41 TM7 Van der Waals
Parathyroid hormone M445 7.43x42 TM7 hydrophobic
Parathyroid hormone M445 7.43x42 TM7 Van der Waals
Parathyroid hormone N448 7.46x45 TM7 polar (hydrogen bond)
Parathyroid hormone N448 7.46x45 TM7 Van der Waals

Ligands

Parathyroid hormone

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x32 1.36x36 F184
1x35 1.39x39 L187
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448