PDB
7VVN
Resolution
3.8 Å
Released
Aug. 3, 2022
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
Function
PTH
Agonist
Reference
10.1016/J.MOLCEL.2022.07.003

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Ligand Amino Acid Generic Number Segment Interaction Type
PTH K34 N-term hydrophobic
PTH Q37 N-term Van der Waals
PTH R162 N-term Van der Waals
PTH R181 N-term Van der Waals
PTH F288 3.36x36 TM3 Van der Waals
PTH L292 3.40x40 TM3 hydrophobic
PTH Y296 3.44x44 TM3 hydrophobic
PTH Q364 5.40x40 TM5 polar (hydrogen bond)
PTH Q364 5.40x40 TM5 hydrophobic
PTH I367 5.43x43 TM5 hydrophobic
PTH L368 5.44x44 TM5 Van der Waals
PTH F424 6.56x56 TM6 polar (hydrogen bond with backbone)
PTH M425 6.57x57 TM6 Van der Waals
PTH T427 ECL3 Van der Waals
PTH P428 ECL3 Van der Waals
PTH T430 ECL3 Van der Waals
PTH E444 7.42x41 TM7 polar (hydrogen bond)
PTH M445 7.43x42 TM7 Van der Waals

PTH

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM3
3x32 3.36x36 F288
3x36 3.40x40 L292
3x40 3.44x44 Y296
TM5
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x51 6.56x56 F424
6x52 6.57x57 M425
TM7
7x37 7.42x41 E444
7x38 7.43x42 M445