PDB
7VVO
Resolution
4.1 Å
Released
Aug. 3, 2022
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
PTH
Function
Agonist
Reference
10.1016/J.MOLCEL.2022.07.003

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Ligand Amino Acid Generic Number Segment Interaction Type
PTH Y195 1.47x47 TM1 polar (hydrogen bond)
PTH Y195 1.47x47 TM1 Van der Waals
PTH I237 2.64x64 TM2 hydrophobic
PTH I237 2.64x64 TM2 Van der Waals
PTH F288 3.36x36 TM3 hydrophobic
PTH F288 3.36x36 TM3 Van der Waals
PTH L289 3.37x37 TM3 Van der Waals
PTH L292 3.40x40 TM3 Van der Waals
PTH L292 3.40x40 TM3 hydrophobic
PTH Y296 3.44x44 TM3 hydrophobic
PTH Y296 3.44x44 TM3 Van der Waals
PTH Q364 5.40x40 TM5 Van der Waals
PTH F424 6.56x56 TM6 polar (hydrogen bond with backbone)
PTH F424 6.56x56 TM6 Van der Waals
PTH M425 6.57x57 TM6 polar (hydrogen bond with backbone)
PTH M425 6.57x57 TM6 Van der Waals
PTH T427 ECL3 polar (hydrogen bond with backbone)
PTH T427 ECL3 Van der Waals
PTH E444 7.42x41 TM7 Van der Waals

PTH

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x43 1.47x47 Y195
TM2
2x57 2.64x64 I237
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
TM5
5x44 5.40x40 Q364
TM6
6x51 6.56x56 F424
6x52 6.57x57 M425
TM7
7x37 7.42x41 E444