PDB
7W0O
Resolution
3.8 Å
Released
July 27, 2022
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
Function
Elabela/Toddler-32 (Human)
Agonist
Reference
10.1038/S41594-022-00797-5

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 aromatic (edge-to-face)
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 hydrophobic
Elabela/Toddler-32 (Human) Y88 2.63x63 TM2 Van der Waals
Elabela/Toddler-32 (Human) Y93 ECL1 hydrophobic
Elabela/Toddler-32 (Human) S105 3.28x28 TM3 Van der Waals
Elabela/Toddler-32 (Human) S106 3.29x29 TM3 Van der Waals
Elabela/Toddler-32 (Human) I109 3.32x32 TM3 hydrophobic
Elabela/Toddler-32 (Human) F110 3.33x33 TM3 Van der Waals
Elabela/Toddler-32 (Human) R168 ECL2 polar (charge-charge)
Elabela/Toddler-32 (Human) R168 ECL2 polar (hydrogen bond)
Elabela/Toddler-32 (Human) L173 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Q180 ECL2 Van der Waals
Elabela/Toddler-32 (Human) C181 45.50x50 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 Van der Waals
Elabela/Toddler-32 (Human) M183 45.52x52 ECL2 hydrophobic
Elabela/Toddler-32 (Human) Y185 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 polar (hydrogen bond)
Elabela/Toddler-32 (Human) K268 6.55x55 TM6 polar (charge-charge)
Elabela/Toddler-32 (Human) Y271 6.58x58 TM6 Van der Waals
Elabela/Toddler-32 (Human) M288 7.32x31 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
2x63 2.63x63 Y88
TM3
3x28 3.28x28 S105
3x29 3.29x29 S106
3x32 3.32x32 I109
3x33 3.33x33 F110
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x31 7.32x31 M288