PDB
7W0P
Resolution
3.2 Å
Released
July 27, 2022
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
Elabela/Toddler-32 (Human)
Function
Agonist
Reference
10.1038/S41594-022-00797-5

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 hydrophobic
Elabela/Toddler-32 (Human) Y93 ECL1 Van der Waals
Elabela/Toddler-32 (Human) Y93 ECL1 polar (hydrogen bond)
Elabela/Toddler-32 (Human) I109 3.32x32 TM3 hydrophobic
Elabela/Toddler-32 (Human) I109 3.32x32 TM3 Van der Waals
Elabela/Toddler-32 (Human) F110 3.33x33 TM3 Van der Waals
Elabela/Toddler-32 (Human) F110 3.33x33 TM3 hydrophobic
Elabela/Toddler-32 (Human) M113 3.36x36 TM3 hydrophobic
Elabela/Toddler-32 (Human) M113 3.36x36 TM3 Van der Waals
Elabela/Toddler-32 (Human) L173 ECL2 Van der Waals
Elabela/Toddler-32 (Human) E174 ECL2 polar (charge-assisted hydrogen bond)
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 hydrophobic
Elabela/Toddler-32 (Human) M183 45.52x52 ECL2 polar (hydrogen bond)
Elabela/Toddler-32 (Human) Y185 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 Van der Waals
Elabela/Toddler-32 (Human) K268 6.55x55 TM6 Van der Waals
Elabela/Toddler-32 (Human) Y271 6.58x58 TM6 hydrophobic
Elabela/Toddler-32 (Human) Y271 6.58x58 TM6 Van der Waals
Elabela/Toddler-32 (Human) L285 7.29x28 TM7 hydrophobic
Elabela/Toddler-32 (Human) L285 7.29x28 TM7 Van der Waals
Elabela/Toddler-32 (Human) F291 7.35x34 TM7 hydrophobic
Elabela/Toddler-32 (Human) F291 7.35x34 TM7 Van der Waals
Elabela/Toddler-32 (Human) P292 7.36x35 TM7 hydrophobic
Elabela/Toddler-32 (Human) P292 7.36x35 TM7 Van der Waals
Elabela/Toddler-32 (Human) Y299 7.43x42 TM7 Van der Waals
Elabela/Toddler-32 (Human) Y299 7.43x42 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
3x36 3.36x36 M113
ECL2
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x28 7.29x28 L285
7x34 7.35x34 F291
7x35 7.36x35 P292
7x42 7.43x42 Y299