Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7W0P

SPECIES

Homo sapiens

RESOLUTION

3.160

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-022-00797-5

PUBLICATION DATE

July 27, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
apelin receptor early endogenous ligand W85 2.60x60 TM2 hydrophobic
apelin receptor early endogenous ligand Y93 ECL1 Van der Waals
apelin receptor early endogenous ligand Y93 ECL1 polar (hydrogen bond)
apelin receptor early endogenous ligand I109 3.32x32 TM3 hydrophobic
apelin receptor early endogenous ligand I109 3.32x32 TM3 Van der Waals
apelin receptor early endogenous ligand F110 3.33x33 TM3 Van der Waals
apelin receptor early endogenous ligand F110 3.33x33 TM3 hydrophobic
apelin receptor early endogenous ligand M113 3.36x36 TM3 hydrophobic
apelin receptor early endogenous ligand M113 3.36x36 TM3 Van der Waals
apelin receptor early endogenous ligand L173 ECL2 Van der Waals
apelin receptor early endogenous ligand E174 ECL2 polar (charge-assisted hydrogen bond)
apelin receptor early endogenous ligand Y182 45.51x51 ECL2 Van der Waals
apelin receptor early endogenous ligand Y182 45.51x51 ECL2 hydrophobic
apelin receptor early endogenous ligand M183 45.52x52 ECL2 polar (hydrogen bond)
apelin receptor early endogenous ligand Y185 ECL2 Van der Waals
apelin receptor early endogenous ligand Y264 6.51x51 TM6 Van der Waals
apelin receptor early endogenous ligand K268 6.55x55 TM6 Van der Waals
apelin receptor early endogenous ligand Y271 6.58x58 TM6 hydrophobic
apelin receptor early endogenous ligand Y271 6.58x58 TM6 Van der Waals
apelin receptor early endogenous ligand L285 7.29x28 TM7 hydrophobic
apelin receptor early endogenous ligand L285 7.29x28 TM7 Van der Waals
apelin receptor early endogenous ligand F291 7.35x34 TM7 hydrophobic
apelin receptor early endogenous ligand F291 7.35x34 TM7 Van der Waals
apelin receptor early endogenous ligand P292 7.36x35 TM7 hydrophobic
apelin receptor early endogenous ligand P292 7.36x35 TM7 Van der Waals
apelin receptor early endogenous ligand Y299 7.43x42 TM7 Van der Waals
apelin receptor early endogenous ligand Y299 7.43x42 TM7 hydrophobic

Ligands

apelin receptor early endogenous ligand

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
3x36 3.36x36 M113
ECL2
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x28 7.29x28 L285
7x34 7.35x34 F291
7x35 7.36x35 P292
7x42 7.43x42 Y299