PDB
7W0P
Resolution
3.2 Å
Released
July 27, 2022
Receptor
apelin
Class
A
Species
Homo sapiens
Ligand
Function
Elabela/Toddler-32 (Human)
Agonist
Reference
10.1038/S41594-022-00797-5

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Ligand Amino Acid Generic Number Segment Interaction Type
Elabela/Toddler-32 (Human) I31 1.35x35 TM1 Van der Waals
Elabela/Toddler-32 (Human) W85 2.60x60 TM2 hydrophobic
Elabela/Toddler-32 (Human) Y88 2.63x63 TM2 Van der Waals
Elabela/Toddler-32 (Human) Y93 ECL1 hydrophobic
Elabela/Toddler-32 (Human) I109 3.32x32 TM3 hydrophobic
Elabela/Toddler-32 (Human) F110 3.33x33 TM3 hydrophobic
Elabela/Toddler-32 (Human) M113 3.36x36 TM3 hydrophobic
Elabela/Toddler-32 (Human) L173 ECL2 hydrophobic
Elabela/Toddler-32 (Human) E174 ECL2 polar (charge-charge)
Elabela/Toddler-32 (Human) Y182 45.51x51 ECL2 Van der Waals
Elabela/Toddler-32 (Human) M183 45.52x52 ECL2 Van der Waals
Elabela/Toddler-32 (Human) Y185 ECL2 Van der Waals
Elabela/Toddler-32 (Human) L201 5.38x39 TM5 Van der Waals
Elabela/Toddler-32 (Human) S205 5.42x43 TM5 Van der Waals
Elabela/Toddler-32 (Human) Y264 6.51x51 TM6 Van der Waals
Elabela/Toddler-32 (Human) K268 6.55x55 TM6 aromatic (pi-cation)
Elabela/Toddler-32 (Human) K268 6.55x55 TM6 polar (charge-charge)
Elabela/Toddler-32 (Human) Y271 6.58x58 TM6 hydrophobic
Elabela/Toddler-32 (Human) L285 7.29x28 TM7 Van der Waals
Elabela/Toddler-32 (Human) F291 7.35x34 TM7 hydrophobic
Elabela/Toddler-32 (Human) P292 7.36x35 TM7 hydrophobic
Elabela/Toddler-32 (Human) T295 7.39x38 TM7 Van der Waals
Elabela/Toddler-32 (Human) Y299 7.43x42 TM7 hydrophobic

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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
Helix box plot — Download: PNG | SVG G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7

GPCRdb(A)
GPCRdb(A)
apelin receptor
TM1
1x35 1.35x35 I31
TM2
2x60 2.60x60 W85
2x63 2.63x63 Y88
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
3x36 3.36x36 M113
ECL2
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM5
5x39 5.38x39 L201
5x43 5.42x43 S205
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x28 7.29x28 L285
7x34 7.35x34 F291
7x35 7.36x35 P292
7x38 7.39x38 T295
7x42 7.43x42 Y299