Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7W2Z

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-27975-9

PUBLICATION DATE

Jan. 19, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Ghrelin Q36 N-term polar (hydrogen bond)
Ghrelin F38 N-term Van der Waals
Ghrelin F38 N-term hydrophobic
Ghrelin L103 2.64x64 TM2 Van der Waals
Ghrelin L103 2.64x64 TM2 hydrophobic
Ghrelin Y106 ECL1 Van der Waals
Ghrelin Y106 ECL1 polar (hydrogen bond)
Ghrelin R107 ECL1 Van der Waals
Ghrelin S123 3.32x32 TM3 polar (hydrogen bond)
Ghrelin S123 3.32x32 TM3 Van der Waals
Ghrelin E124 3.33x33 TM3 Van der Waals
Ghrelin E187 ECL2 polar (charge-assisted hydrogen bond)
Ghrelin E197 ECL2 polar (charge-assisted hydrogen bond)
Ghrelin E202 ECL2 Van der Waals
Ghrelin L210 5.36x36 TM5 Van der Waals
Ghrelin M213 5.39x39 TM5 Van der Waals
Ghrelin V214 5.40x40 TM5 Van der Waals
Ghrelin V214 5.40x40 TM5 hydrophobic
Ghrelin F279 6.51x51 TM6 hydrophobic
Ghrelin F279 6.51x51 TM6 Van der Waals
Ghrelin R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
Ghrelin F286 6.58x58 TM6 Van der Waals
Ghrelin F286 6.58x58 TM6 hydrophobic
Ghrelin S289 6.61x61 TM6 Van der Waals
Ghrelin F290 6.62x62 TM6 hydrophobic
Ghrelin F290 6.62x62 TM6 Van der Waals
Ghrelin S294 ECL3 Van der Waals
Ghrelin L295 7.25x24 TM7 Van der Waals
Ghrelin L295 7.25x24 TM7 hydrophobic
Ghrelin A298 7.28x27 TM7 hydrophobic
Ghrelin A298 7.28x27 TM7 Van der Waals
Ghrelin Q302 7.32x31 TM7 Van der Waals
Ghrelin Q302 7.32x31 TM7 polar (hydrogen bond)
Ghrelin N305 7.35x34 TM7 polar (hydrogen bond)
Ghrelin L306 7.36x35 TM7 hydrophobic
Ghrelin L306 7.36x35 TM7 Van der Waals
Ghrelin S308 7.38x37 TM7 Van der Waals

Ligands

Ghrelin

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x64 2.64x64 L103
TM3
3x32 3.32x32 S123
3x33 3.33x33 E124
TM5
5x36 5.36x36 L210
5x39 5.39x39 M213
5x40 5.40x40 V214
TM6
6x51 6.51x51 F279
6x55 6.55x55 R283
6x58 6.58x58 F286
6x61 6.61x61 S289
6x62 6.62x62 F290
TM7
7x24 7.25x24 L295
7x27 7.28x27 A298
7x31 7.32x31 Q302
7x34 7.35x34 N305
7x35 7.36x35 L306
7x37 7.38x37 S308