PDB
7WF7
Resolution
3.4 Å
Released
Jan. 5, 2022
Receptor
S1P1
Class
A
Species
Homo sapiens
Ligand
sphingosine 1-phosphate
Function
Agonist
Reference
10.1038/S41589-021-00930-3

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Ligand Amino Acid Generic Number Segment Interaction Type
sphingosine 1-phosphate R120 3.28x28 TM3 polar (charge-assisted hydrogen bond)
sphingosine 1-phosphate E121 3.29x29 TM3 Van der Waals
sphingosine 1-phosphate G122 3.30x30 TM3 Van der Waals
sphingosine 1-phosphate M124 3.32x32 TM3 hydrophobic
sphingosine 1-phosphate M124 3.32x32 TM3 Van der Waals
sphingosine 1-phosphate F125 3.33x33 TM3 hydrophobic
sphingosine 1-phosphate F125 3.33x33 TM3 Van der Waals
sphingosine 1-phosphate L195 ECL2 hydrophobic
sphingosine 1-phosphate L297 7.39x38 TM7 Van der Waals
sphingosine 1-phosphate L297 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
Helix box plot — Download: PNG | SVG I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7

GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x30 3.30x30 G122
3x32 3.32x32 M124
3x33 3.33x33 F125
TM7
7x38 7.39x38 L297