PDB
7WF7
Resolution
3.4 Å
Released
Jan. 5, 2022
Receptor
S1P1
Class
A
Species
Homo sapiens
Ligand
Function
sphingosine 1-phosphate
Agonist
Reference
10.1038/S41589-021-00930-3

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Ligand Amino Acid Generic Number Segment Interaction Type
sphingosine 1-phosphate Y29 N-term Van der Waals
sphingosine 1-phosphate K34 N-term polar (charge-charge)
sphingosine 1-phosphate N101 2.60x60 TM2 Van der Waals
sphingosine 1-phosphate T109 23.50x50 ECL1 Van der Waals
sphingosine 1-phosphate R120 3.28x28 TM3 Van der Waals
sphingosine 1-phosphate E121 3.29x29 TM3 hydrophobic
sphingosine 1-phosphate G122 3.30x30 TM3 Van der Waals
sphingosine 1-phosphate M124 3.32x32 TM3 hydrophobic
sphingosine 1-phosphate F125 3.33x33 TM3 hydrophobic
sphingosine 1-phosphate L195 ECL2 Van der Waals
sphingosine 1-phosphate L272 6.51x51 TM6 Van der Waals
sphingosine 1-phosphate L297 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
Helix box plot — Download: PNG | SVG I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7

GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
ECL1
23x50 23.50x50 T109
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x30 3.30x30 G122
3x32 3.32x32 M124
3x33 3.33x33 F125
TM6
6x51 6.51x51 L272
TM7
7x38 7.39x38 L297