PDB
7WIG
Resolution
2.7 Å
Released
June 1, 2022
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
CHEMBL69303
Function
Agonist
Reference
10.1038/S41422-022-00669-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL69303 D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL69303 Q126 3.36x36 TM3 Van der Waals
CHEMBL69303 Q126 3.36x36 TM3 polar (hydrogen bond)
CHEMBL69303 Y205 5.35x36 TM5 Van der Waals
CHEMBL69303 F272 6.51x51 TM6 hydrophobic
CHEMBL69303 F272 6.51x51 TM6 Van der Waals
CHEMBL69303 F275 6.54x54 TM6 aromatic (edge-to-face)
CHEMBL69303 F275 6.54x54 TM6 Van der Waals
CHEMBL69303 N276 6.55x55 TM6 Van der Waals
CHEMBL69303 S279 6.58x58 TM6 Van der Waals
CHEMBL69303 L290 7.31x30 TM7 hydrophobic
CHEMBL69303 L290 7.31x30 TM7 Van der Waals
CHEMBL69303 F294 7.35x34 TM7 hydrophobic
CHEMBL69303 F294 7.35x34 TM7 Van der Waals
CHEMBL69303 V298 7.39x38 TM7 hydrophobic
CHEMBL69303 Y302 7.43x42 TM7 polar (hydrogen bond)
CHEMBL69303 Y302 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
TM5
5x36 5.35x36 Y205
TM6
6x51 6.51x51 F272
6x54 6.54x54 F275
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x30 7.31x30 L290
7x34 7.35x34 F294
7x38 7.39x38 V298
7x42 7.43x42 Y302