PDB
7WU5
Resolution
3.0 Å
Released
April 27, 2022
Receptor
ADGRF1
Class
B2
Species
Homo sapiens
Ligand
LPC 16:0
Function
Allosteric agonist
Reference
10.1038/S41586-022-04580-W

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Ligand Amino Acid Generic Number Segment Interaction Type
LPC 16:0 I625 2.48x48 TM2 hydrophobic
LPC 16:0 W674 3.46x46 TM3 hydrophobic
LPC 16:0 M677 3.49x49 TM3 hydrophobic
LPC 16:0 I680 3.52x52 TM3 hydrophobic
LPC 16:0 A683 3.55x55 TM3 hydrophobic
LPC 16:0 Y684 3.56x56 TM3 hydrophobic
LPC 16:0 I687 3.59x59 TM3 hydrophobic
LPC 16:0 L688 3.60x60 TM3 hydrophobic
LPC 16:0 M693 ICL2 hydrophobic
LPC 16:0 M698 4.41x42 TM4 hydrophobic
LPC 16:0 M699 4.42x43 TM4 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K Q I K K ICL1ECL1 D T T V N P ECL1ICL2 V F H H M ICL2ECL2 P S N T Y K R K D V C W L N W S N G S ECL2ICL3 P T V G E R L S R ICL3ECL3 Q ECL3N-term M K V G V L W L I S F F T F T D G H G G F L G K N D G I K T K K E L I V N K K K H L G P V E E Y Q L L L Q V T Y R D S K E K R D L R N F L K L L K P P L L W S H G L I R I I R A K A T T D C N S L N G V L Q C T C E D S Y T W F P P S C L D P Q N C Y L H T A G A L P S C E C H L N N L S Q S V N F C E R T K I W G T F K I N E R F T N D L L N S S S A I Y S K Y A N G I E I Q L K K A Y E R I Q G F E S V Q V T Q F R N G S I V A G Y E V V G S S S A S E L L S A I E H V A E K A K T A L H K L F P L E D G S F R V F G K A Q C N D I V F G F G S K D D E Y T L P C S S G Y R G N I T A K C E S S G W Q V I R E T C V L N-termC-term W K Q T E K Q N S S D L S A K P K F S K P F N P L Q N K G H Y A F S H T G D S S D N I M L T Q F V S N E C-term P S T I F P V V K W I T Y V G L G I S I G S L I L C L I I E A L F W S Q T S H T R R I C M V N I A L S L L I A D V W F I V G A T V S G V C T A A V F F T H F F Y L S L F F W M L M L G I L L A Y R I I L A Q H L M M A V G F C L G Y G C P L I I S V I T I A V T Q K P L L A F V V P A L A I V A V N F V V V L L V L T K L W R D D K A T I I R V G K S L L I L T P L L G L T W G F G I G T I V D S N L A W H V I F A L L N A F Q G F F I L C F G I L L D S K L F N L S S L R Q L K L S A
Helix box plot — Download: PNG | SVG I L S G I S I G L G V Y T I W K V V P F 1 V N I A L S L L I A D V W F I V G A T V 2 M L M W F F L S L Y F F H T F F V A A T 3 M M A V G F C G L Y G C P L I I S V I T I 4 V V V F N V A V I A L A P V V F A L L P 5 L I L T P L L G L T W G F G I G T I V D 6 C L I F F G Q F A N L L A F I V H W A 7

GPCRdb(A)
GPCRdb(B)
ADGRF1
TM2
2x41 2.48x48 I625
TM3
3x42 3.46x46 W674
3x45 3.49x49 M677
3x48 3.52x52 I680
3x51 3.55x55 A683
3x52 3.56x56 Y684
3x55 3.59x59 I687
3x56 3.60x60 L688
TM4
4x42 4.41x42 M698
4x43 4.42x43 M699