PDB
7WVV
Resolution
2.9 Å
Released
April 13, 2022
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
N-formyl-MLFII (fM5)
Function
Agonist
Reference
10.1038/S41467-022-29361-X

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Ligand Amino Acid Generic Number Segment Interaction Type
N-formyl-MLFII (fM5) V105 3.32x32 TM3 hydrophobic
N-formyl-MLFII (fM5) D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
N-formyl-MLFII (fM5) L109 3.36x36 TM3 hydrophobic
N-formyl-MLFII (fM5) L109 3.36x36 TM3 Van der Waals
N-formyl-MLFII (fM5) F110 3.37x37 TM3 hydrophobic
N-formyl-MLFII (fM5) F110 3.37x37 TM3 Van der Waals
N-formyl-MLFII (fM5) T177 45.51x51 ECL2 Van der Waals
N-formyl-MLFII (fM5) F178 45.52x52 ECL2 hydrophobic
N-formyl-MLFII (fM5) F178 45.52x52 ECL2 Van der Waals
N-formyl-MLFII (fM5) R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
N-formyl-MLFII (fM5) R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
N-formyl-MLFII (fM5) W254 6.48x48 TM6 hydrophobic
N-formyl-MLFII (fM5) W254 6.48x48 TM6 Van der Waals
N-formyl-MLFII (fM5) F257 6.51x51 TM6 hydrophobic
N-formyl-MLFII (fM5) F257 6.51x51 TM6 Van der Waals
N-formyl-MLFII (fM5) Q258 6.52x52 TM6 Van der Waals
N-formyl-MLFII (fM5) A261 6.55x55 TM6 Van der Waals
N-formyl-MLFII (fM5) A261 6.55x55 TM6 hydrophobic
N-formyl-MLFII (fM5) G264 6.58x58 TM6 Van der Waals
N-formyl-MLFII (fM5) T265 6.59x59 TM6 Van der Waals
N-formyl-MLFII (fM5) L268 ECL3 hydrophobic
N-formyl-MLFII (fM5) L268 ECL3 Van der Waals
N-formyl-MLFII (fM5) V284 7.35x34 TM7 Van der Waals
N-formyl-MLFII (fM5) V284 7.35x34 TM7 hydrophobic
N-formyl-MLFII (fM5) F292 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM3
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
6x55 6.55x55 A261
6x58 6.58x58 G264
6x59 6.59x59 T265
TM7
7x34 7.35x34 V284
7x42 7.43x42 F292