PDB
7WVW
Resolution
3.1 Å
Released
April 13, 2022
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
fM9
Function
Agonist
Reference
10.1038/S41467-022-29361-X

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Ligand Amino Acid Generic Number Segment Interaction Type
fM9 L81 2.60x60 TM2 hydrophobic
fM9 V105 3.32x32 TM3 hydrophobic
fM9 D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
fM9 L109 3.36x36 TM3 hydrophobic
fM9 L109 3.36x36 TM3 Van der Waals
fM9 F110 3.37x37 TM3 hydrophobic
fM9 F110 3.37x37 TM3 Van der Waals
fM9 Y175 ECL2 Van der Waals
fM9 Y175 ECL2 hydrophobic
fM9 T177 45.51x51 ECL2 Van der Waals
fM9 T177 45.51x51 ECL2 polar (hydrogen bond)
fM9 F178 45.52x52 ECL2 Van der Waals
fM9 F178 45.52x52 ECL2 hydrophobic
fM9 L198 5.35x36 TM5 Van der Waals
fM9 L198 5.35x36 TM5 hydrophobic
fM9 R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
fM9 R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
fM9 G209 5.46x461 TM5 Van der Waals
fM9 W254 6.48x48 TM6 Van der Waals
fM9 F257 6.51x51 TM6 Van der Waals
fM9 F257 6.51x51 TM6 hydrophobic
fM9 Q258 6.52x52 TM6 Van der Waals
fM9 L272 ECL3 hydrophobic
fM9 L272 ECL3 Van der Waals
fM9 V284 7.35x34 TM7 hydrophobic
fM9 V284 7.35x34 TM7 Van der Waals
fM9 F292 7.43x42 TM7 Van der Waals
fM9 F292 7.43x42 TM7 hydrophobic

fM9

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x60 2.60x60 L81
TM3
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
TM7
7x34 7.35x34 V284
7x42 7.43x42 F292