PDB
7WVX
Resolution
2.8 Å
Released
April 13, 2022
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
Function
fhumanin
Agonist
Reference
10.1038/S41467-022-29361-X

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Ligand Amino Acid Generic Number Segment Interaction Type
fhumanin G88 2.67x67 TM2 Van der Waals
fhumanin E89 ECL1 polar (hydrogen bond)
fhumanin E89 ECL1 hydrophobic
fhumanin V105 3.32x32 TM3 Van der Waals
fhumanin D106 3.33x33 TM3 polar (hydrogen bond)
fhumanin L109 3.36x36 TM3 hydrophobic
fhumanin F110 3.37x37 TM3 hydrophobic
fhumanin V113 3.40x40 TM3 hydrophobic
fhumanin V167 ECL2 Van der Waals
fhumanin I169 ECL2 hydrophobic
fhumanin Y175 ECL2 hydrophobic
fhumanin Y175 ECL2 aromatic (edge-to-face)
fhumanin F178 45.52x52 ECL2 hydrophobic
fhumanin N179 ECL2 polar (hydrogen bond)
fhumanin F180 ECL2 polar (hydrogen bond with backbone)
fhumanin F180 ECL2 hydrophobic
fhumanin A181 ECL2 hydrophobic
fhumanin R190 5.27x28 TM5 hydrophobic
fhumanin L191 5.28x29 TM5 Van der Waals
fhumanin A194 5.31x32 TM5 hydrophobic
fhumanin L198 5.35x36 TM5 hydrophobic
fhumanin R201 5.38x39 TM5 polar (hydrogen bond)
fhumanin R205 5.42x43 TM5 hydrophobic
fhumanin G209 5.46x461 TM5 Van der Waals
fhumanin W254 6.48x48 TM6 hydrophobic
fhumanin F257 6.51x51 TM6 hydrophobic
fhumanin Q258 6.52x52 TM6 Van der Waals
fhumanin G264 6.58x58 TM6 Van der Waals
fhumanin L268 ECL3 Van der Waals
fhumanin M271 ECL3 Van der Waals
fhumanin L272 ECL3 hydrophobic
fhumanin V284 7.35x34 TM7 hydrophobic
fhumanin S288 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x67 2.67x67 G88
TM3
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x52 45.52x52 F178
TM5
5x28 5.27x28 R190
5x29 5.28x29 L191
5x32 5.31x32 A194
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
6x58 6.58x58 G264
TM7
7x34 7.35x34 V284
7x38 7.39x38 S288