PDB
7WVY
Resolution
3.0 Å
Released
April 13, 2022
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
Aβ42
Function
Agonist
Reference
10.1038/S41467-022-29361-X

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Ligand Amino Acid Generic Number Segment Interaction Type
Aβ42 M85 2.64x64 TM2 hydrophobic
Aβ42 D106 3.33x33 TM3 polar (hydrogen bond with backbone)
Aβ42 D106 3.33x33 TM3 Van der Waals
Aβ42 L109 3.36x36 TM3 hydrophobic
Aβ42 L109 3.36x36 TM3 Van der Waals
Aβ42 F110 3.37x37 TM3 Van der Waals
Aβ42 F110 3.37x37 TM3 polar (hydrogen bond with backbone)
Aβ42 V113 3.40x40 TM3 Van der Waals
Aβ42 V113 3.40x40 TM3 hydrophobic
Aβ42 L164 ECL2 Van der Waals
Aβ42 F178 45.52x52 ECL2 polar (hydrogen bond with backbone)
Aβ42 F178 45.52x52 ECL2 Van der Waals
Aβ42 N179 ECL2 Van der Waals
Aβ42 F180 ECL2 hydrophobic
Aβ42 F180 ECL2 Van der Waals
Aβ42 R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
Aβ42 R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Aβ42 G209 5.46x461 TM5 polar (hydrogen bond with backbone)
Aβ42 G209 5.46x461 TM5 Van der Waals
Aβ42 W254 6.48x48 TM6 Van der Waals
Aβ42 F257 6.51x51 TM6 Van der Waals
Aβ42 F257 6.51x51 TM6 hydrophobic
Aβ42 Q258 6.52x52 TM6 polar (hydrogen bond)
Aβ42 Q258 6.52x52 TM6 Van der Waals
Aβ42 A261 6.55x55 TM6 Van der Waals
Aβ42 A261 6.55x55 TM6 hydrophobic
Aβ42 L272 ECL3 Van der Waals
Aβ42 L272 ECL3 hydrophobic
Aβ42 D281 7.32x31 TM7 Van der Waals
Aβ42 V284 7.35x34 TM7 hydrophobic
Aβ42 V284 7.35x34 TM7 Van der Waals
Aβ42 N285 7.36x35 TM7 polar (hydrogen bond)
Aβ42 N285 7.36x35 TM7 Van der Waals
Aβ42 S288 7.39x38 TM7 Van der Waals

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ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x64 2.64x64 M85
TM3
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
ECL2
45x52 45.52x52 F178
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
6x55 6.55x55 A261
TM7
7x31 7.32x31 D281
7x34 7.35x34 V284
7x35 7.36x35 N285
7x38 7.39x38 S288