Ligands
Function
Agonist
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| fenoldopam (F:502) | K81 | 2.61x60 | TM2 | Van der Waals |
| fenoldopam (F:502) | W99 | 3.28x28 | TM3 | hydrophobic |
| fenoldopam (F:502) | V100 | 3.29x29 | TM3 | Van der Waals |
| fenoldopam (F:503) | D103 | 3.32x32 | TM3 | polar (charge-charge) |
| fenoldopam (F:502) | D103 | 3.32x32 | TM3 | polar (hydrogen bond) |
| fenoldopam (F:503) | D103 | 3.32x32 | TM3 | polar (hydrogen bond) |
| fenoldopam (F:503) | I104 | 3.33x33 | TM3 | hydrophobic |
| fenoldopam (F:503) | S107 | 3.36x36 | TM3 | Van der Waals |
| fenoldopam (F:503) | T108 | 3.37x37 | TM3 | Van der Waals |
| fenoldopam (F:503) | S188 | 45.52x52 | ECL2 | Van der Waals |
| fenoldopam (F:502) | S188 | 45.52x52 | ECL2 | Van der Waals |
| fenoldopam (F:502) | S189 | ECL2 | polar (hydrogen bond) | |
| fenoldopam (F:502) | L190 | ECL2 | Van der Waals | |
| fenoldopam (F:503) | L190 | ECL2 | hydrophobic | |
| fenoldopam (F:503) | Y194 | 5.38x39 | TM5 | Van der Waals |
| fenoldopam (F:503) | S198 | 5.42x43 | TM5 | polar (hydrogen bond) |
| fenoldopam (F:503) | S198 | 5.42x43 | TM5 | polar (hydrogen bond) |
| fenoldopam (F:503) | S202 | 5.46x461 | TM5 | Van der Waals |
| fenoldopam (F:503) | W285 | 6.48x48 | TM6 | Van der Waals |
| fenoldopam (F:503) | F288 | 6.51x51 | TM6 | hydrophobic |
| fenoldopam (F:503) | F288 | 6.51x51 | TM6 | aromatic (edge-to-face) |
| fenoldopam (F:503) | F289 | 6.52x52 | TM6 | hydrophobic |
| fenoldopam (F:503) | F289 | 6.52x52 | TM6 | aromatic (edge-to-face) |
| fenoldopam (F:503) | N292 | 6.55x55 | TM6 | Van der Waals |
| fenoldopam (F:502) | S310 | 7.32x31 | TM7 | Van der Waals |
| fenoldopam (F:502) | F313 | 7.35x34 | TM7 | hydrophobic |
| fenoldopam (F:503) | F313 | 7.35x34 | TM7 | Van der Waals |
| fenoldopam (F:502) | D314 | 7.36x35 | TM7 | polar (charge-charge) |
| fenoldopam (F:502) | D314 | 7.36x35 | TM7 | polar (hydrogen bond) |
| fenoldopam (F:502) | V317 | 7.39x38 | TM7 | Van der Waals |
| fenoldopam (F:503) | W321 | 7.43x42 | TM7 | Van der Waals |
| fenoldopam (F:502) | W321 | 7.43x42 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
D1 receptor
|
|---|---|---|
| TM2 | ||
| 2x60 | 2.61x60 | K81 |
| TM3 | ||
| 3x28 | 3.28x28 | W99 |
| 3x29 | 3.29x29 | V100 |
| 3x32 | 3.32x32 | D103 |
| 3x33 | 3.33x33 | I104 |
| 3x36 | 3.36x36 | S107 |
| 3x37 | 3.37x37 | T108 |
| ECL2 | ||
| 45x52 | 45.52x52 | S188 |
| TM5 | ||
| 5x39 | 5.38x39 | Y194 |
| 5x43 | 5.42x43 | S198 |
| 5x461 | 5.46x461 | S202 |
| TM6 | ||
| 6x48 | 6.48x48 | W285 |
| 6x51 | 6.51x51 | F288 |
| 6x52 | 6.52x52 | F289 |
| 6x55 | 6.55x55 | N292 |
| TM7 | ||
| 7x31 | 7.32x31 | S310 |
| 7x34 | 7.35x34 | F313 |
| 7x35 | 7.36x35 | D314 |
| 7x38 | 7.39x38 | V317 |
| 7x42 | 7.43x42 | W321 |