PDB
7X8R
Resolution
2.6 Å
Released
June 29, 2022
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Function
CHEMBL2158411
Agonist
Reference
10.1073/PNAS.2200155119

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL2158411 S31 N-term Van der Waals
CHEMBL2158411 W33 N-term aromatic (edge-to-face)
CHEMBL2158411 W33 N-term hydrophobic
CHEMBL2158411 Q140 1.35x35 TM1 hydrophobic
CHEMBL2158411 L141 1.36x36 TM1 hydrophobic
CHEMBL2158411 L144 1.39x39 TM1 Van der Waals
CHEMBL2158411 Y145 1.40x40 TM1 Van der Waals
CHEMBL2158411 Y148 1.43x43 TM1 Van der Waals
CHEMBL2158411 Y152 1.47x47 TM1 Van der Waals
CHEMBL2158411 V194 2.64x64 TM2 hydrophobic
CHEMBL2158411 K197 2.67x67 TM2 aromatic (pi-cation)
CHEMBL2158411 A200 2.70x70 TM2 hydrophobic
CHEMBL2158411 L201 2.71x71 TM2 hydrophobic
CHEMBL2158411 C226 3.29x29 TM3 hydrophobic
CHEMBL2158411 V229 3.32x32 TM3 hydrophobic
CHEMBL2158411 F230 3.33x33 TM3 Van der Waals
CHEMBL2158411 M233 3.36x36 TM3 Van der Waals
CHEMBL2158411 C296 45.50x50 ECL2 hydrophobic
CHEMBL2158411 T298 45.52x52 ECL2 hydrophobic
CHEMBL2158411 R299 ECL2 polar (hydrogen bond)
CHEMBL2158411 R299 ECL2 polar (charge-charge)
CHEMBL2158411 R380 7.35x34 TM7 polar (charge-charge)
CHEMBL2158411 F381 7.36x35 TM7 hydrophobic
CHEMBL2158411 L388 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x31 1.35x35 Q140
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x57 2.64x64 V194
2x60 2.67x67 K197
2x63 2.70x70 A200
2x64 2.71x71 L201
TM3
3x25 3.29x29 C226
3x28 3.32x32 V229
3x29 3.33x33 F230
3x32 3.36x36 M233
ECL2
45x50 45.50x50 C296
45x52 45.52x52 T298
TM7
7x30 7.35x34 R380
7x31 7.36x35 F381
7x38 7.43x42 L388