Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XAU

SPECIES

Homo sapiens

RESOLUTION

2.970

PREFERRED CHAIN

A

REFERENCE

10.1038/S41421-022-00405-2

PUBLICATION DATE

Aug. 31, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octreotide L99 2.60x60 TM2 hydrophobic
Octreotide F127 3.37x37 TM3 hydrophobic
Octreotide I177 4.60x61 TM4 hydrophobic
Octreotide Y205 ECL2 aromatic (face-to-face)
Octreotide F208 5.38x39 TM5 hydrophobic
Octreotide I209 5.39x40 TM5 hydrophobic
Octreotide N276 6.55x55 TM6 polar (hydrogen bond)
Octreotide N276 6.55x55 TM6 polar (hydrogen bond)
Octreotide S279 6.58x58 TM6 Van der Waals
Octreotide S279 6.58x58 TM6 polar (hydrogen bond)
Octreotide S279 6.58x58 TM6 polar (hydrogen bond)
Octreotide P286 ECL3 Van der Waals
Octreotide P286 ECL3 hydrophobic
Octreotide F294 7.35x34 TM7 hydrophobic
Octreotide F294 7.35x34 TM7 Van der Waals
Octreotide V298 7.39x38 TM7 hydrophobic
Octreotide V298 7.39x38 TM7 Van der Waals
Octreotide Y302 7.43x42 TM7 Van der Waals
Octreotide Y302 7.43x42 TM7 hydrophobic

Ligands

Octreotide

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM2
2x60 2.60x60 L99
TM3
3x37 3.37x37 F127
TM4
4x61 4.60x61 I177
TM5
5x39 5.38x39 F208
5x40 5.39x40 I209
TM6
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x34 7.35x34 F294
7x38 7.39x38 V298
7x42 7.43x42 Y302