PDB
7XAV
Resolution
2.9 Å
Released
Aug. 31, 2022
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
Function
LANREOTIDE
Agonist
Reference
10.1038/S41421-022-00405-2

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Ligand Amino Acid Generic Number Segment Interaction Type
LANREOTIDE L99 2.60x60 TM2 Van der Waals
LANREOTIDE D122 3.32x32 TM3 Van der Waals
LANREOTIDE Q126 3.36x36 TM3 Van der Waals
LANREOTIDE F127 3.37x37 TM3 hydrophobic
LANREOTIDE T194 45.51x51 ECL2 polar (hydrogen bond)
LANREOTIDE Y205 ECL2 polar (hydrogen bond with backbone)
LANREOTIDE Y205 ECL2 aromatic (face-to-face)
LANREOTIDE Y205 ECL2 hydrophobic
LANREOTIDE T206 ECL2 Van der Waals
LANREOTIDE F208 5.38x39 TM5 hydrophobic
LANREOTIDE F208 5.38x39 TM5 polar (hydrogen bond with backbone)
LANREOTIDE I209 5.39x40 TM5 hydrophobic
LANREOTIDE T212 5.42x43 TM5 covalent bond
LANREOTIDE F272 6.51x51 TM6 hydrophobic
LANREOTIDE N276 6.55x55 TM6 Van der Waals
LANREOTIDE S279 6.58x58 TM6 polar (hydrogen bond)
LANREOTIDE F294 7.35x34 TM7 hydrophobic
LANREOTIDE V298 7.39x38 TM7 hydrophobic
LANREOTIDE Y302 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM2
2x60 2.60x60 L99
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
3x37 3.37x37 F127
ECL2
45x51 45.51x51 T194
TM5
5x39 5.38x39 F208
5x40 5.39x40 I209
5x43 5.42x43 T212
TM6
6x51 6.51x51 F272
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x34 7.35x34 F294
7x38 7.39x38 V298
7x42 7.43x42 Y302