PDB
7XBW
Resolution
2.8 Å
Released
July 13, 2022
Receptor
CX3CR1
Class
A
Species
Homo sapiens
Ligands
Function
Cholesterol (R:402)
PAM
Cholesterol (R:401)
PAM
Cholesterol (R:403)
PAM
Reference
10.1126/SCIADV.ABN8048
Cholesterol (R:402) Cholesterol (R:401) Cholesterol (R:403)

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol (R:401) L71 2.44x44 TM2 Van der Waals
Cholesterol (R:401) N72 2.45x45 TM2 Van der Waals
Cholesterol (R:401) L75 2.48x48 TM2 hydrophobic
Cholesterol (R:401) L79 2.52x52 TM2 hydrophobic
Cholesterol (R:401) I111 3.34x34 TM3 Van der Waals
Cholesterol (R:402) F118 3.41x41 TM3 hydrophobic
Cholesterol (R:402) T121 3.44x44 TM3 Van der Waals
Cholesterol (R:402) V122 3.45x45 TM3 hydrophobic
Cholesterol (R:402) I125 3.48x48 TM3 Van der Waals
Cholesterol (R:402) T142 ICL2 Van der Waals
Cholesterol (R:402) T148 4.44x44 TM4 polar (hydrogen bond)
Cholesterol (R:402) I149 4.45x45 TM4 Van der Waals
Cholesterol (R:401) S150 4.46x46 TM4 Van der Waals
Cholesterol (R:401) L151 4.47x47 TM4 hydrophobic
Cholesterol (R:402) G152 4.48x48 TM4 Van der Waals
Cholesterol (R:402) V153 4.49x49 TM4 hydrophobic
Cholesterol (R:401) W154 4.50x50 TM4 hydrophobic
Cholesterol (R:402) A156 4.52x52 TM4 Van der Waals
Cholesterol (R:401) I158 4.54x54 TM4 hydrophobic
Cholesterol (R:402) L198 5.45x46 TM5 hydrophobic
Cholesterol (R:402) L202 5.49x49 TM5 hydrophobic
Cholesterol (R:402) P203 5.50x50 TM5 hydrophobic
Cholesterol (R:403) L205 5.52x52 TM5 hydrophobic
Cholesterol (R:402) I206 5.53x53 TM5 hydrophobic
Cholesterol (R:403) S208 5.55x55 TM5 Van der Waals
Cholesterol (R:403) Y209 5.56x56 TM5 Van der Waals
Cholesterol (R:403) F212 5.59x59 TM5 hydrophobic
Cholesterol (R:403) I215 5.62x62 TM5 hydrophobic
Cholesterol (R:403) F219 5.66x66 TM5 hydrophobic
Cholesterol (R:403) L234 6.38x38 TM6 hydrophobic

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NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 K K P K ICL1ECL1 E K G L H N A ECL1ICL2 A A N S M N N R ICL2ECL2 K Q K E N E C L G D Y P E V ECL2ICL3 K N ICL3ECL3 F F P ECL3N-term M D Q F P E S V T E N F E Y D D L A E A C Y N-termC-term C L A V L C G R S V H V D F S S S E S Q R S R H G S V L S S N F T Y H T S D G D A L L L L C-term I G D I V V F G T V F L S I F Y S V I F A I G L V G N L L V V F A L T N S S V T D I Y L L N L A L S D L L F V A T L P F W T H Y L I N M C K F T T A F F F I G F F G S I F F I T V I S I D R Y L A I V L T V Q H G V T I S L G V W A A A I L V A A P Q F M F T L Q E I W P V L R N V E T N F L G F L L P L L I M S Y C Y F R I I Q T L F S C H K K A K A I K L I L L V V I V F F L F W T P Y N V M I F L E T L K L Y D S C D M R K D L R L A L S V T E T V A F S H C C L N P L I Y A F A G E K L Y H F R R Y L Y G K
Helix box plot — Download: PNG | SVG L N G V L G I A F I V S Y F I S L F V T 1 L N L A L S D L L F V A T L P F W T H Y 2 V T I F F I S G F F G I F F F A T T F K 3 G V T I S L G V W A A A I L V A A P Q 4 Y C Y S M I L L P L L F G L F N T E V N R 5 L L V V I V F F L F W T P Y N V M I F L 6 L P N L C C H S F A V T E T V S L A L 7

GPCRdb(A)
GPCRdb(A)
CX3CR1
TM2
2x44 2.44x44 L71
2x45 2.45x45 N72
2x48 2.48x48 L75
2x52 2.52x52 L79
TM3
3x34 3.34x34 I111
3x41 3.41x41 F118
3x44 3.44x44 T121
3x45 3.45x45 V122
3x48 3.48x48 I125
TM4
4x44 4.44x44 T148
4x45 4.45x45 I149
4x46 4.46x46 S150
4x47 4.47x47 L151
4x48 4.48x48 G152
4x49 4.49x49 V153
4x50 4.50x50 W154
4x52 4.52x52 A156
4x54 4.54x54 I158
TM5
5x46 5.45x46 L198
5x49 5.49x49 L202
5x50 5.50x50 P203
5x52 5.52x52 L205
5x53 5.53x53 I206
5x55 5.55x55 S208
5x56 5.56x56 Y209
5x59 5.59x59 F212
5x62 5.62x62 I215
5x66 5.66x66 F219
TM6
6x38 6.38x38 L234