PDB
7XBX
Resolution
3.4 Å
Released
July 13, 2022
Receptor
CX3CR1
Class
A
Species
Homo sapiens
Ligands
Function
Cholesterol (R:501)
PAM
Cholesterol (R:502)
PAM
Reference
—
Cholesterol (R:501) Cholesterol (R:502)

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol (R:501) F220 3.41x41 TM3 hydrophobic
Cholesterol (R:501) T223 3.44x44 TM3 hydrophobic
Cholesterol (R:501) V224 3.45x45 TM3 Van der Waals
Cholesterol (R:501) H247 4.41x41 TM4 Van der Waals
Cholesterol (R:501) T250 4.44x44 TM4 polar (hydrogen bond)
Cholesterol (R:501) I251 4.45x45 TM4 hydrophobic
Cholesterol (R:501) G254 4.48x48 TM4 Van der Waals
Cholesterol (R:501) V255 4.49x49 TM4 Van der Waals
Cholesterol (R:501) A258 4.52x52 TM4 Van der Waals
Cholesterol (R:501) L300 5.45x46 TM5 Van der Waals
Cholesterol (R:501) L304 5.49x49 TM5 hydrophobic
Cholesterol (R:501) P305 5.50x50 TM5 hydrophobic
Cholesterol (R:502) S310 5.55x55 TM5 Van der Waals
Cholesterol (R:502) F314 5.59x59 TM5 hydrophobic
Cholesterol (R:502) I317 5.62x62 TM5 Van der Waals
Cholesterol (R:502) F321 5.66x66 TM5 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K P K ICL1ECL1 E K G L H N A ECL1ICL2 A A N S M N N R ICL2ECL2 K Q K E N E C L G D Y P E V ECL2ICL3 K N ICL3ECL3 F F P ECL3N-term M D Q F P E S V T E N F E Y D D L A E A C Y N-termC-term C L A V L C G R S V H V D F S S S E S Q R S R H G S V L S S N F T Y H T S D G D A L L L L C-term I G D I V V F G T V F L S I F Y S V I F A I G L V G N L L V V F A L T N S S V T D I Y L L N L A L S D L L F V A T L P F W T H Y L I N M C K F T T A F F F I G F F G S I F F I T V I S I D R Y L A I V L T V Q H G V T I S L G V W A A A I L V A A P Q F M F T L Q E I W P V L R N V E T N F L G F L L P L L I M S Y C Y F R I I Q T L F S C H K K A K A I K L I L L V V I V F F L F W T P Y N V M I F L E T L K L Y D S C D M R K D L R L A L S V T E T V A F S H C C L N P L I Y A F A G E K L Y H F R R Y L Y G K
Helix box plot — Download: PNG | SVG L N G V L G I A F I V S Y F I S L F V T 1 L N L A L S D L L F V A T L P F W T H Y 2 V T I F F I S G F F G I F F F A T T F K 3 G V T I S L G V W A A A I L V A A P Q 4 Y C Y S M I L L P L L F G L F N T E V N R 5 L L V V I V F F L F W T P Y N V M I F L 6 L P N L C C H S F A V T E T V S L A L 7

GPCRdb(A)
GPCRdb(A)
CX3CR1
TM3
3x41 3.41x41 F118
3x44 3.44x44 T121
3x45 3.45x45 V122
TM4
4x41 4.41x41 H145
4x44 4.44x44 T148
4x45 4.45x45 I149
4x48 4.48x48 G152
4x49 4.49x49 V153
4x52 4.52x52 A156
TM5
5x46 5.45x46 L198
5x49 5.49x49 L202
5x50 5.50x50 P203
5x55 5.55x55 S208
5x59 5.59x59 F212
5x62 5.62x62 I215
5x66 5.66x66 F219