PDB
7XJJ
Resolution
3.3 Å
Released
May 3, 2023
Receptor
GAL1
Class
A
Species
Homo sapiens
Ligand
galanin(1-13)amide
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
galanin(1-13)amide Q92 2.61x60 TM2 polar (hydrogen bond)
galanin(1-13)amide Q92 2.61x60 TM2 polar (hydrogen bond)
galanin(1-13)amide V95 2.64x63 TM2 Van der Waals
galanin(1-13)amide V95 2.64x63 TM2 hydrophobic
galanin(1-13)amide Y96 2.65x64 TM2 Van der Waals
galanin(1-13)amide L98 2.67x66 TM2 Van der Waals
galanin(1-13)amide P99 ECL1 polar (hydrogen bond with backbone)
galanin(1-13)amide P99 ECL1 Van der Waals
galanin(1-13)amide T100 23.49x49 ECL1 Van der Waals
galanin(1-13)amide H112 3.29x29 TM3 Van der Waals
galanin(1-13)amide H112 3.29x29 TM3 aromatic (face-to-edge)
galanin(1-13)amide H112 3.29x29 TM3 polar (hydrogen bond)
galanin(1-13)amide F186 ECL2 Van der Waals
galanin(1-13)amide F186 ECL2 hydrophobic
galanin(1-13)amide C187 45.50x50 ECL2 Van der Waals
galanin(1-13)amide W188 45.51x51 ECL2 polar (hydrogen bond)
galanin(1-13)amide V274 ECL3 hydrophobic
galanin(1-13)amide F275 ECL3 hydrophobic
galanin(1-13)amide F275 ECL3 Van der Waals
galanin(1-13)amide L277 ECL3 hydrophobic
galanin(1-13)amide L277 ECL3 Van der Waals
galanin(1-13)amide T278 7.28x27 TM7 polar (hydrogen bond with backbone)
galanin(1-13)amide T278 7.28x27 TM7 Van der Waals
galanin(1-13)amide S281 7.31x30 TM7 polar (hydrogen bond)
galanin(1-13)amide F282 7.32x31 TM7 polar (hydrogen bond with backbone)
galanin(1-13)amide F282 7.32x31 TM7 Van der Waals
galanin(1-13)amide R285 7.35x34 TM7 Van der Waals

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ICL1 K P G K P R ICL1ECL1 P T W V L ECL1ICL2 S R R S S S L R ICL2ECL2 G L F H P R A S N Q T F C W E Q W P ECL2ICL3 K N M ICL3ECL3 V F P L ECL3N-term M E L A V G N L S E G N A S W P E P P A P E P G P L F G I N-termC-term C H I R K D S H L S D T K E S K S R I D T P P S T N C T H V C-term G V E N F V T L V V F G L I F A L G V L G N S L V I T V L A R S S T T N L F I L N L S I A D L A Y L L F C I P F Q A T V Y A L G A F I C K F I H Y F F T V S M L V S I F T L A A M S V D R Y V A I V H V S R N A L L G V G C I W A L S I A M A S P V A Y H Q D P R H K K A Y V V C T F V F G Y L L P L L L I C F C Y A K V L N H L H K K L S K K S E A S K K K T A Q T V L V V V V V F G I S W L P H H I I H L W A E F G T P A S F L F R I T A H C L A Y S N S S V N P I I Y A F L S E N Y K Q F R K A V F K
Helix box plot — Download: PNG | SVG S N G L V G L A F I L G F V V L T V F N 1 L N L S I A D L A Y L F L C I P F Q A T V 2 A A L T F I S V L M S V T F F Y H I F K 3 A L L G V G C I W A L S I A M A S P V 4 Y C F C I L L L P L L Y G F V F T C V V Y 5 L V V V V V F G I S W L P H H I I H L W 6 I P N V S S N S Y A L C H A T I R F L 7

GPCRdb(A)
GPCRdb(A)
GAL1 receptor
TM2
2x60 2.61x60 Q92
2x63 2.64x63 V95
2x64 2.65x64 Y96
2x66 2.67x66 L98
ECL1
23x49 23.49x49 T100
TM3
3x29 3.29x29 H112
ECL2
45x50 45.50x50 C187
45x51 45.51x51 W188
TM7
7x27 7.28x27 T278
7x30 7.31x30 S281
7x31 7.32x31 F282
7x34 7.35x34 R285