PDB
7XKF
Resolution
2.4 Å
Released
Aug. 10, 2022
Receptor
ADGRG2
Class
B2
Species
Mus musculus
Ligand
PRASTERONE
Function
Agonist
Reference
10.1038/S41589-022-01084-6

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Ligand Amino Acid Generic Number Segment Interaction Type
PRASTERONE L620 1.39x39 TM1 hydrophobic
PRASTERONE F671 2.64x64 TM2 hydrophobic
PRASTERONE W838 6.53x53 TM6 hydrophobic
PRASTERONE F856 7.42x41 TM7 hydrophobic

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ICL1 E K I R R ICL1ECL1 N ECL1ICL2 V F N T Y I R ICL2ECL2 P D N Y G I G S Y G K F P N G T P D D F C W I N S ECL2ICL3 Q L G A Q R K ICL3ECL3 P V N ECL3N-term M L F S G G Q Y S P V G R P E E V L L I Y K I F L V I I C F H V I L V T S L K E N G N S S L L S P S A E S S L V S L I P Y S N G T P D A A S E V L S T L N K T E K S K I T I V K T F N A S G V K S Q R N I C N L S S L C N D S V F F R G E I V F Q H D E D H N V T Q N Q D T A N G T F A G V L S L S E L K R S E L N K T L Q T L S E T Y F I V C A T A E A Q S T V N C T F T V K L N E T M N V C A M M V T F Q T V Q I R P M E Q C C C S P R T P C P S S P E E L E K L Q C E L Q D P I V C L A D Q P H G P P L S S S S K P V V P Q A T I I S H V A S D F S L A E P L D H A L M T P S T P S L T Q E S N L P S P Q P T I P L A S S P A T D L P V Q S V V V S S L P Q T D L S H T L S P V Q S S I P S P T T P A P S V P T E L V T I S T P P G E T V V N T S T V S D L E A Q V S Q M E K A L S L G S L E P N L A G E M V N R V S K L L H S P P A L L A P L A Q R L L K V V D A I G L Q L N F S S T T I S L T S P S L A L A V I R V N A S N F N T T T F A A Q D P T N L Q V S L E T P P P E N S I G A I T L P S S L M N N L P A N D V E L A S R I Q F N F F E T P A L F Q D P S L E N L T L I S Y V I S S S V T N M T I K N L T R N V T V A L K H I N P S P D D L T V K C V F W D L G R N G G K G G W S S D G C S V K D K R M N E T I C T C S H L T S F G I L L D L S R T S L P N-termC-term R L A E N S D W S K T A T N G L K K Q T V N Q G V S S S S N S L Q S S C N S T N S T T L L V N S D C S V H A S G N G N A S T E R N G V S F S V Q N G D V C L H D L T G K Q H M F S D K E D S C N G K S R I A L R R T S K R G S L H F I E Q M C-term P S Q M M A L T F I T Y I G C G L S S I F L S V T L V T Y I A F D Y P S K I L I Q L C A A L L L L N L I F L L D S W I A L Y T R G F C I A V A V F L H Y F L L V S F T W M G L E A F H M Y L A L V K K Y I L K F C I V G W G I P A V V V S I V L T I S N V V F Y I T V V G Y F C V I F L L N V S M F I V V L V Q L C R I K K K K T S I Q D L R S I A G L T F L L G I T W G F A F F A W G V T F M Y L F A I F N T L Q G F F I F I F Y C A A K E N W R R G K L V R K Q Y L C C
Helix box plot — Download: PNG | SVG S L F I S S L G C G I Y T I F T L A M M 1 I Q L C A A L L L L N L I F L L D S W I 2 L G M W T F S V L L F Y H L F V A V A I 3 Y I L K F C I G V W G I P A V V V S I V L 4 F M S V N L L F I V C F Y G V V T I Y F V 5 A G L T F L L G I T W G F A F F A W G 6 I F I F F G Q L T N F I A F L Y M F T 7

GPCRdb(A)
GPCRdb(B)
ADGRG2
TM1
1x35 1.39x39 L620
TM2
2x57 2.64x64 F671
TM6
6x48 6.53x53 W838
TM7
7x37 7.42x41 F856