Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XMR

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-022-00679-X

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
SOMATOSTATIN Q126 3.36x36 TM3 Van der Waals
SOMATOSTATIN R184 ECL2 polar (charge-assisted hydrogen bond)
SOMATOSTATIN N186 ECL2 Van der Waals
SOMATOSTATIN N186 ECL2 polar (hydrogen bond)
SOMATOSTATIN S192 ECL2 polar (hydrogen bond)
SOMATOSTATIN S192 ECL2 polar (hydrogen bond)
SOMATOSTATIN T194 45.51x51 ECL2 polar (hydrogen bond)
SOMATOSTATIN W197 ECL2 Van der Waals
SOMATOSTATIN W197 ECL2 aromatic (edge-to-face)
SOMATOSTATIN S201 ECL2 Van der Waals
SOMATOSTATIN Y205 5.35x36 TM5 polar (hydrogen bond)
SOMATOSTATIN Y205 5.35x36 TM5 Van der Waals
SOMATOSTATIN Y205 5.35x36 TM5 aromatic (edge-to-face)
SOMATOSTATIN F208 5.38x39 TM5 Van der Waals
SOMATOSTATIN F208 5.38x39 TM5 hydrophobic
SOMATOSTATIN T212 5.42x43 TM5 Van der Waals
SOMATOSTATIN F275 6.54x54 TM6 hydrophobic
SOMATOSTATIN N276 6.55x55 TM6 Van der Waals
SOMATOSTATIN N276 6.55x55 TM6 polar (hydrogen bond)
SOMATOSTATIN S279 6.58x58 TM6 Van der Waals
SOMATOSTATIN S279 6.58x58 TM6 polar (hydrogen bond)
SOMATOSTATIN V280 6.59x59 TM6 polar (hydrogen bond with backbone)
SOMATOSTATIN V280 6.59x59 TM6 Van der Waals
SOMATOSTATIN I284 ECL3 Van der Waals
SOMATOSTATIN I284 ECL3 hydrophobic
SOMATOSTATIN K291 7.32x31 TM7 Van der Waals
SOMATOSTATIN F294 7.35x34 TM7 aromatic (face-to-face)
SOMATOSTATIN F294 7.35x34 TM7 Van der Waals
SOMATOSTATIN Y302 7.43x42 TM7 polar (hydrogen bond)
SOMATOSTATIN Y302 7.43x42 TM7 Van der Waals

Ligands

SOMATOSTATIN

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x51 45.51x51 T194
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
5x43 5.42x43 T212
TM6
6x54 6.54x54 F275
6x55 6.55x55 N276
6x58 6.58x58 S279
6x59 6.59x59 V280
TM7
7x31 7.32x31 K291
7x34 7.35x34 F294
7x42 7.43x42 Y302