Structure information

CCK2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XOX

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-022-00420-3

PUBLICATION DATE

July 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CCK-8 P114 2.64x63 TM2 hydrophobic
CCK-8 M134 3.32x32 TM3 polar (hydrogen bond)
CCK-8 V138 3.36x36 TM3 Van der Waals
CCK-8 V138 3.36x36 TM3 hydrophobic
CCK-8 Y189 4.60x61 TM4 polar (hydrogen bond)
CCK-8 Q204 ECL2 polar (hydrogen bond)
CCK-8 Q204 ECL2 polar (hydrogen bond)
CCK-8 C205 45.50x50 ECL2 polar (hydrogen bond with backbone)
CCK-8 C205 45.50x50 ECL2 Van der Waals
CCK-8 H207 45.52x52 ECL2 polar (hydrogen bond)
CCK-8 H207 45.52x52 ECL2 Van der Waals
CCK-8 N353 6.55x55 TM6 polar (hydrogen bond)
CCK-8 N353 6.55x55 TM6 Van der Waals
CCK-8 R356 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CCK-8 A363 ECL3 Van der Waals
CCK-8 A363 ECL3 hydrophobic
CCK-8 H364 ECL3 Van der Waals
CCK-8 S368 ECL3 Van der Waals
CCK-8 I372 7.35x34 TM7 Van der Waals
CCK-8 I372 7.35x34 TM7 hydrophobic
CCK-8 H376 7.39x38 TM7 polar (hydrogen bond)
CCK-8 H376 7.39x38 TM7 polar (hydrogen bond)
CCK-8 Y380 7.43x42 TM7 Van der Waals

Ligands

CCK-8

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Residue Diagrams

M N G G V S M L F I V A Y L T I R I A L 1 L S L A V S D L L L A A V C M P F T L L P 2 A V L S L T S V S V S V G M L Y S V A K 3 A A R V I V A T W L L S G L L M V P Y 4 Y A V A M V V G P I F F L L L L L L V S W 5 L V I V V L F F L C W L P V Y S A N T W 6 L P N V C A S A Y S L L H I F S I P A 7
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ICL1 R R L R ICL1ECL1 T F I F ECL1ICL2 P L Q A R V W Q ICL2ECL2 V V Q P V G P R V L Q C V H R W P ECL2ICL3 S D S Q S R V R N Q G G L P G A V H Q N G R C R P E T G A V G E D S D G C Y V Q L P R S R P A L E L T A L T A P G P G S G S R P T ICL3ECL3 P G A H R A L S ECL3N-term M E L L K L N R S V Q G T G P G P G A S L C R P G A P L L N S S S V G N L S C E P P R I R G A G T R E N-termC-term A R C C P R P P R A R P R A L P D E D P P T P S I A S L S R L S Y T T I S T L G P G C-term L E L A I R I T L Y A V I F L M S V G G N M L I I V V L G L S T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R T R S H A A R V I V A T W L L S G L L M V P Y P V Y T S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G L R F D G D S D Q A K L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R C L E F R Q A T C
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCK2 receptor
TM2
2x63 2.64x63 P114
TM3
3x32 3.32x32 M134
3x36 3.36x36 V138
TM4
4x61 4.60x61 Y189
ECL2
45x50 45.50x50 C205
45x52 45.52x52 H207
TM6
6x55 6.55x55 N353
6x58 6.58x58 R356
TM7
7x34 7.35x34 I372
7x38 7.39x38 H376
7x42 7.43x42 Y380