PDB
7XP6
Resolution
3.0 Å
Released
Oct. 12, 2022
Receptor
TAS2R46
Class
T2
Species
Homo sapiens
Ligand
strychnine
Function
Agonist
Reference
10.1126/SCIENCE.ABO1633

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Ligand Amino Acid Generic Number Segment Interaction Type
strychnine L62 2.57x57 TM2 hydrophobic
strychnine Y85 3.29x29 TM3 hydrophobic
strychnine W88 3.32x32 TM3 hydrophobic
strychnine T180 5.43x44 TM5 polar (hydrogen bond)
strychnine T180 5.43x44 TM5 Van der Waals
strychnine E265 7.39x38 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
Helix box plot — Download: PNG | SVG G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7

GPCRdb(A)
GPCRdb(A)
TAS2R46
TM2
2x57 2.57x57 L62
TM3
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM5
5x44 5.43x44 T180
TM7
7x38 7.39x38 E265