PDB
7XT9
Resolution
3.2 Å
Released
July 27, 2022
Receptor
5-HT4
Class
A
Species
Homo sapiens
Ligand
Function
5-hydroxytryptamine
Agonist
Reference
10.1016/J.MOLCEL.2022.05.031

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Ligand Amino Acid Generic Number Segment Interaction Type
5-hydroxytryptamine D99 3.32x32 TM3 polar (charge-charge)
5-hydroxytryptamine D99 3.32x32 TM3 polar (hydrogen bond)
5-hydroxytryptamine V100 3.33x33 TM3 hydrophobic
5-hydroxytryptamine T103 3.36x36 TM3 Van der Waals
5-hydroxytryptamine T104 3.37x37 TM3 polar (hydrogen bond)
5-hydroxytryptamine F185 45.52x52 ECL2 hydrophobic
5-hydroxytryptamine V187 ECL2 Van der Waals
5-hydroxytryptamine Y191 5.38x39 TM5 Van der Waals
5-hydroxytryptamine C195 5.42x43 TM5 hydrophobic
5-hydroxytryptamine A199 5.46x461 TM5 Van der Waals
5-hydroxytryptamine F274 6.51x51 TM6 Van der Waals
5-hydroxytryptamine F275 6.52x52 TM6 hydrophobic
5-hydroxytryptamine F275 6.52x52 TM6 aromatic (edge-to-face)
5-hydroxytryptamine N278 6.55x55 TM6 polar (hydrogen bond)
5-hydroxytryptamine L297 7.39x38 TM7 Van der Waals
5-hydroxytryptamine Y301 7.43x42 TM7 Van der Waals

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ICL1 R Q L R K ICL1ECL1 I W I Y ECL1ICL2 P Q L V Y R N K M ICL2ECL2 W N N I G I I D L I E K R K F N Q N S N S T Y C V F M V ECL2ICL3 A S S E S R P Q S A D Q H S ICL3ECL3 D Y T V ECL3N-term M D K L D A N V S S E E G F G S N-termC-term D D E R Y R R P S I L G Q T V P C S T T T I N G S T H V L R D A V E C G G Q W E S Q C H P P A T S P L V A A Q P S D T C-term V E K V V L L T F L S T V I L M A I L G N L L V M V A V C W D I K T N Y F I V S L A F A D L L V S V L V M P F G A I E L V Q D G E V F C L V R T S L D V L L T T A S I F H L C C I S L D R Y Y A I C C T P L R I A L M L G G C W V I P T F I S F L P I M Q G N K P Y A I T C S V V A F Y I P F L L M V L A Y Y R I Y V T A K E H A H Q I Q M L Q R A G T H R M R T E T K A A K T L C I I M G C F C L C W A P F F V T N I V D P F I P G Q V W T A F L W L G Y I N S G L N P F L Y A F L N K S F L I F R R A I L C C
Helix box plot — Download: PNG | SVG L N G L I A M L I V T S L F T L L V V K 1 V S L A F A D L L V S L V V M P F G A I E 2 C C L H F I S A T T L L V D L S T R V L 3 I A L M L G G C W V I P T F I S F L P I 4 Y A L V M L L F P I Y F A V V S C T I A Y 5 C I I M G C F C L C W A P F F V T N I V 6 F P N L G S N I Y G L W L F A T W V Q 7

GPCRdb(A)
GPCRdb(A)
5-HT4 receptor
TM3
3x32 3.32x32 D100
3x33 3.33x33 V101
3x36 3.36x36 T104
3x37 3.37x37 T105
ECL2
45x52 45.52x52 F186
TM5
5x39 5.38x39 Y192
5x43 5.42x43 C196
5x461 5.46x461 A200
TM6
6x51 6.51x51 F275
6x52 6.52x52 F276
6x55 6.55x55 N279
TM7
7x38 7.39x38 L298
7x42 7.43x42 Y302