PDB
7XV3
Resolution
2.8 Å
Released
Feb. 15, 2023
Receptor
GPR174
Class
A
Species
Homo sapiens
Ligand
LysoPS(18:0)
Function
Agonist
Reference
10.1038/S41467-023-36575-0

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Ligand Amino Acid Generic Number Segment Interaction Type
LysoPS(18:0) R75 2.60x60 TM2 polar (charge-assisted hydrogen bond)
LysoPS(18:0) Y79 2.64x64 TM2 Van der Waals
LysoPS(18:0) Y79 2.64x64 TM2 polar (hydrogen bond)
LysoPS(18:0) F95 3.29x29 TM3 hydrophobic
LysoPS(18:0) F95 3.29x29 TM3 Van der Waals
LysoPS(18:0) Y99 3.33x33 TM3 Van der Waals
LysoPS(18:0) Y99 3.33x33 TM3 polar (hydrogen bond)
LysoPS(18:0) Y103 3.37x37 TM3 hydrophobic
LysoPS(18:0) Y103 3.37x37 TM3 Van der Waals
LysoPS(18:0) Y107 3.41x41 TM3 hydrophobic
LysoPS(18:0) Y107 3.41x41 TM3 Van der Waals
LysoPS(18:0) I145 4.53x53 TM4 hydrophobic
LysoPS(18:0) F152 4.60x60 TM4 Van der Waals
LysoPS(18:0) F152 4.60x60 TM4 hydrophobic
LysoPS(18:0) R156 4.64x64 TM4 polar (charge-assisted hydrogen bond)
LysoPS(18:0) F169 45.51x51 ECL2 polar (hydrogen bond with backbone)
LysoPS(18:0) F169 45.51x51 ECL2 Van der Waals
LysoPS(18:0) Y246 6.51x51 TM6 polar (hydrogen bond)
LysoPS(18:0) F250 6.55x55 TM6 hydrophobic
LysoPS(18:0) F250 6.55x55 TM6 Van der Waals
LysoPS(18:0) F254 6.59x59 TM6 hydrophobic
LysoPS(18:0) F254 6.59x59 TM6 Van der Waals
LysoPS(18:0) K257 6.62x62 TM6 polar (charge-assisted hydrogen bond)
LysoPS(18:0) H274 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K R A ICL1ECL1 D W P F ECL1ICL2 P F R F H D C ICL2ECL2 T S D D T S G N R T K C F V D L P T R N V ECL2ICL3 Q D K Y P M A Q D L ICL3ECL3 E I K ECL3N-term M P A N Y T C T R P D G D N T D N-termC-term H D S I Q L H A K S F V S N H T A S T M T P E L C C-term F R Y F I Y A V T Y T V I L V P G L I G N I L A L W V F Y G Y M K E T V I F M I N L A I A D L L Q V L S L P L R I F Y Y L N H G P G L C M F C F Y L K Y V N M Y A S I Y F L V C I S V R R F W F L M Y K Q K Y D L Y I S I A G W L I I C L A C V L F P L L R N L A Q S V V M M T I G E L I G F V T P L L I V L Y C T W K T V L S L G E K Q K A L K M I L T C A G V F L I C F A P Y H F S F P L D F L V K S N S C L A R R V I L I F H S V A L C L A S L N S C L D P V I Y Y F S T N E L S R F R R R Q D L
Helix box plot — Download: PNG | SVG I N G I L G P V L I V T Y T V A Y I F Y 1 I N L A I A D L L Q V L S L P L R I F Y 2 C V L F Y I S A Y M N V Y K L Y F C F M 3 D L Y I S I A G W L I I C L A C V L F P 4 T C Y L V I L L P T V F G I L E G I T M M 5 L T C A G V F L I C F A P Y H F S F P L 6 V P D L C S N L S A L C L A V S H F I 7

GPCRdb(A)
GPCRdb(A)
GPR174
TM2
2x60 2.60x60 R75
2x64 2.64x64 Y79
TM3
3x29 3.29x29 F95
3x33 3.33x33 Y99
3x37 3.37x37 Y103
3x41 3.41x41 Y107
TM4
4x53 4.53x53 I145
4x60 4.60x60 F152
4x64 4.64x64 R156
ECL2
45x51 45.51x51 F169
TM6
6x51 6.51x51 Y246
6x55 6.55x55 F250
6x59 6.59x59 F254
6x62 6.62x62 K257
TM7
7x34 7.35x34 H274