PDB
7XXH
Resolution
2.9 Å
Released
June 7, 2023
Receptor
P2Y1
Class
A
Species
Homo sapiens
Ligand
Function
2MeSADP
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
2MeSADP C42 N-term Van der Waals
2MeSADP T45 N-term hydrophobic
2MeSADP Y110 2.63x63 TM2 polar (hydrogen bond)
2MeSADP Y111 2.64x64 TM2 polar (hydrogen bond)
2MeSADP T115 ECL1 Van der Waals
2MeSADP R128 3.29x29 TM3 polar (charge-charge)
2MeSADP R128 3.29x29 TM3 polar (hydrogen bond)
2MeSADP T201 ECL2 Van der Waals
2MeSADP C202 45.50x50 ECL2 Van der Waals
2MeSADP Y203 45.51x51 ECL2 Van der Waals
2MeSADP D204 45.52x52 ECL2 Van der Waals
2MeSADP T205 ECL2 Van der Waals
2MeSADP T206 ECL2 polar (hydrogen bond with backbone)
2MeSADP R287 6.62x62 TM6 polar (hydrogen bond)
2MeSADP Q291 ECL3 Van der Waals
2MeSADP Y303 7.32x31 TM7 Van der Waals
2MeSADP Y306 7.35x34 TM7 Van der Waals
2MeSADP R310 7.39x38 TM7 polar (charge-charge)

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Snake plot — Download: PNG | SVG
ICL1 M K P W ICL1ECL1 K T D W I F ECL1ICL2 P L K S L G R L ICL2ECL2 G T G V R K N K T I T C Y D T T S D E Y ECL2ICL3 D L D N S ICL3ECL3 F Q T P A ECL3N-term M T E V L W P A V P N G T D A A F L A G P G S S W G N S T V A S T A A V S S S F K C A L T K T G N-termC-term K A S R R S E A N L Q S K S E D M T L N I L P E F K Q N G D T S L C-term F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y K K K N A I C I S V L V W L I V V V A I S P I L F Y S L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D M C A F N D R V Y A T Y Q V T R G L A S L N S C V D P I L Y F L A G D T L S R F R R R A T R
Helix box plot — Download: PNG | SVG S N G L F G I I F V L I Y V A P L Y Y F 1 F N L A L A D F L Y V L T L P A L I F Y 2 C T L F L I S G Y L N V H F I F R Q L K 3 A I C I S V L V W L I V V V A I S P I L 4 Y C G L I L V L P V C F M A V T T C M S Y 5 V I I V L T V F V A S Y I P F H V M K T M 6 I P D V C S N L S A L G R T V Q Y T A 7

GPCRdb(A)
GPCRdb(A)
P2Y1 receptor
TM2
2x63 2.63x63 Y110
2x64 2.64x64 Y111
TM3
3x29 3.29x29 R128
ECL2
45x50 45.50x50 C202
45x51 45.51x51 Y203
45x52 45.52x52 D204
TM6
6x62 6.62x62 R287
TM7
7x31 7.32x31 Y303
7x34 7.35x34 Y306
7x38 7.39x38 R310