Structure information

A2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XY6

SPECIES

Homo sapiens

RESOLUTION

2.990

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADD3709

PUBLICATION DATE

May 3, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
BAY 60-6583 Y10 1.35x35 TM1 polar (hydrogen bond)
BAY 60-6583 A64 2.61x60 TM2 Van der Waals
BAY 60-6583 S68 2.65x64 TM2 Van der Waals
BAY 60-6583 L86 3.33x33 TM3 hydrophobic
BAY 60-6583 L86 3.33x33 TM3 Van der Waals
BAY 60-6583 T89 3.36x36 TM3 Van der Waals
BAY 60-6583 F173 45.52x52 ECL2 Van der Waals
BAY 60-6583 F173 45.52x52 ECL2 aromatic (face-to-face)
BAY 60-6583 E174 ECL2 polar (charge-assisted hydrogen bond)
BAY 60-6583 M182 5.38x40 TM5 hydrophobic
BAY 60-6583 M182 5.38x40 TM5 Van der Waals
BAY 60-6583 N186 5.42x43 TM5 Van der Waals
BAY 60-6583 W247 6.48x48 TM6 Van der Waals
BAY 60-6583 W247 6.48x48 TM6 hydrophobic
BAY 60-6583 H251 6.52x52 TM6 Van der Waals
BAY 60-6583 N254 6.55x55 TM6 polar (hydrogen bond)
BAY 60-6583 M272 7.35x34 TM7 Van der Waals
BAY 60-6583 N273 7.36x35 TM7 polar (hydrogen bond)
BAY 60-6583 I276 7.39x38 TM7 Van der Waals
BAY 60-6583 I276 7.39x38 TM7 hydrophobic

Ligands

BAY 60-6583

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Residue Diagrams

V N G A V S L A A I V L E L A V Y L A D 1 V S L A A A D V A V G F L A I P F A I T I 2 A L L S F I S S Q T L V L V F C A L F L 3 A R G V I A V L W V L A F G I G L T P F 4 Y I V L M I L L P P L V C G F F N F Y V M Y 5 A M I V G I F A L C W L P V H A V N C V 6 I P N V V S N A H S L L I A M N M A W 7
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ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2B receptor
TM1
1x35 1.35x35 Y10
TM2
2x60 2.61x60 A64
2x64 2.65x64 S68
TM3
3x33 3.33x33 L86
3x36 3.36x36 T89
ECL2
45x52 45.52x52 F173
TM5
5x40 5.38x40 M182
5x43 5.42x43 N186
TM6
6x48 6.48x48 W247
6x52 6.52x52 H251
6x55 6.55x55 N254
TM7
7x34 7.35x34 M272
7x35 7.36x35 N273
7x38 7.39x38 I276