PDB
7XY7
Resolution
3.3 Å
Released
May 3, 2023
Receptor
A2B
Class
A
Species
Homo sapiens
Ligand
Function
NECA
Agonist
Reference
10.1126/SCIADV.ADD3709

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
NECA L86 3.33x33 TM3 Van der Waals
NECA T89 3.36x36 TM3 Van der Waals
NECA Q90 3.37x37 TM3 Van der Waals
NECA I93 3.40x40 TM3 Van der Waals
NECA F173 45.52x52 ECL2 aromatic (face-to-face)
NECA M182 5.38x40 TM5 Van der Waals
NECA N186 5.42x43 TM5 Van der Waals
NECA W247 6.48x48 TM6 Van der Waals
NECA V250 6.51x51 TM6 Van der Waals
NECA H251 6.52x52 TM6 Van der Waals
NECA N254 6.55x55 TM6 Van der Waals
NECA M272 7.35x34 TM7 Van der Waals
NECA I276 7.39x38 TM7 Van der Waals
NECA S279 7.42x41 TM7 polar (hydrogen bond)
NECA H280 7.43x42 TM7 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
Helix box plot — Download: PNG | SVG V N G A V S L A A I V L E L A V Y L A D 1 V S L A A A D V A V G F L A I P F A I T I 2 A L L S F I S S Q T L V L V F C A L F L 3 A R G V I A V L W V L A F G I G L T P F 4 Y I V L M I L L P P L V C G F F N F Y V M Y 5 A M I V G I F A L C W L P V H A V N C V 6 I P N V V S N A H S L L I A M N M A W 7

GPCRdb(A)
GPCRdb(A)
A2B receptor
TM3
3x33 3.33x33 L86
3x36 3.36x36 T89
3x37 3.37x37 Q90
3x40 3.40x40 I93
ECL2
45x52 45.52x52 F173
TM5
5x40 5.38x40 M182
5x43 5.42x43 N186
TM6
6x48 6.48x48 W247
6x51 6.51x51 V250
6x52 6.52x52 H251
6x55 6.55x55 N254
TM7
7x34 7.35x34 M272
7x38 7.39x38 I276
7x41 7.42x41 S279
7x42 7.43x42 H280