PDB
7Y24
Resolution
3.3 Å
Released
Oct. 19, 2022
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
Function
octreotide
Agonist
Reference
10.1038/S41589-022-01130-3

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Ligand Amino Acid Generic Number Segment Interaction Type
octreotide L99 2.60x60 TM2 hydrophobic
octreotide M119 3.29x29 TM3 Van der Waals
octreotide D122 3.32x32 TM3 polar (charge-charge)
octreotide Q126 3.36x36 TM3 polar (hydrogen bond)
octreotide N186 ECL2 Van der Waals
octreotide Q187 ECL2 polar (hydrogen bond with backbone)
octreotide S192 ECL2 Van der Waals
octreotide I195 45.52x52 ECL2 hydrophobic
octreotide N196 ECL2 Van der Waals
octreotide Y205 5.35x36 TM5 hydrophobic
octreotide F208 5.38x39 TM5 aromatic (edge-to-face)
octreotide I209 5.39x40 TM5 hydrophobic
octreotide T212 5.42x43 TM5 hydrophobic
octreotide F272 6.51x51 TM6 Van der Waals
octreotide N276 6.55x55 TM6 polar (hydrogen bond)
octreotide S279 6.58x58 TM6 polar (hydrogen bond)
octreotide V280 6.59x59 TM6 hydrophobic
octreotide L290 7.31x30 TM7 Van der Waals
octreotide K291 7.32x31 TM7 Van der Waals
octreotide F294 7.35x34 TM7 hydrophobic
octreotide V298 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM2
2x60 2.60x60 L99
TM3
3x29 3.29x29 M119
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
5x40 5.39x40 I209
5x43 5.42x43 T212
TM6
6x51 6.51x51 F272
6x55 6.55x55 N276
6x58 6.58x58 S279
6x59 6.59x59 V280
TM7
7x30 7.31x30 L290
7x31 7.32x31 K291
7x34 7.35x34 F294
7x38 7.39x38 V298