PDB
7Y27
Resolution
3.5 Å
Released
Oct. 19, 2022
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
SOMATOSTATIN
Function
Agonist
Reference
10.1038/S41589-022-01130-3

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Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
SOMATOSTATIN Q126 3.36x36 TM3 polar (hydrogen bond)
SOMATOSTATIN N186 ECL2 Van der Waals
SOMATOSTATIN T194 45.51x51 ECL2 Van der Waals
SOMATOSTATIN I195 45.52x52 ECL2 hydrophobic
SOMATOSTATIN I195 45.52x52 ECL2 Van der Waals
SOMATOSTATIN Y205 5.35x36 TM5 Van der Waals
SOMATOSTATIN Y205 5.35x36 TM5 hydrophobic
SOMATOSTATIN F208 5.38x39 TM5 hydrophobic
SOMATOSTATIN F208 5.38x39 TM5 Van der Waals
SOMATOSTATIN S279 6.58x58 TM6 Van der Waals
SOMATOSTATIN K291 7.32x31 TM7 Van der Waals
SOMATOSTATIN F294 7.35x34 TM7 hydrophobic
SOMATOSTATIN F294 7.35x34 TM7 Van der Waals
SOMATOSTATIN Y302 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
TM6
6x58 6.58x58 S279
TM7
7x31 7.32x31 K291
7x34 7.35x34 F294
7x42 7.43x42 Y302