PDB
7Y27
Resolution
3.5 Å
Released
Oct. 19, 2022
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
Function
SOMATOSTATIN
Agonist
Reference
10.1038/S41589-022-01130-3

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Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN F92 2.53x53 TM2 Van der Waals
SOMATOSTATIN L99 2.60x60 TM2 Van der Waals
SOMATOSTATIN M119 3.29x29 TM3 Van der Waals
SOMATOSTATIN D122 3.32x32 TM3 polar (hydrogen bond)
SOMATOSTATIN D122 3.32x32 TM3 polar (charge-charge)
SOMATOSTATIN Q126 3.36x36 TM3 polar (hydrogen bond)
SOMATOSTATIN R184 ECL2 Van der Waals
SOMATOSTATIN N186 ECL2 Van der Waals
SOMATOSTATIN S192 ECL2 Van der Waals
SOMATOSTATIN T194 45.51x51 ECL2 Van der Waals
SOMATOSTATIN I195 45.52x52 ECL2 hydrophobic
SOMATOSTATIN Y205 5.35x36 TM5 hydrophobic
SOMATOSTATIN Y205 5.35x36 TM5 aromatic (edge-to-face)
SOMATOSTATIN F208 5.38x39 TM5 hydrophobic
SOMATOSTATIN F208 5.38x39 TM5 aromatic (edge-to-face)
SOMATOSTATIN T212 5.42x43 TM5 hydrophobic
SOMATOSTATIN F272 6.51x51 TM6 Van der Waals
SOMATOSTATIN S279 6.58x58 TM6 Van der Waals
SOMATOSTATIN I284 ECL3 Van der Waals
SOMATOSTATIN P286 ECL3 hydrophobic
SOMATOSTATIN K291 7.32x31 TM7 aromatic (pi-cation)
SOMATOSTATIN F294 7.35x34 TM7 hydrophobic
SOMATOSTATIN Y302 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM2
2x53 2.53x53 F92
2x60 2.60x60 L99
TM3
3x29 3.29x29 M119
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
5x43 5.42x43 T212
TM6
6x51 6.51x51 F272
6x58 6.58x58 S279
TM7
7x31 7.32x31 K291
7x34 7.35x34 F294
7x42 7.43x42 Y302