Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7Y35

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 5, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
abaloparatide M32 N-term polar (hydrogen bond with backbone)
abaloparatide M32 N-term Van der Waals
abaloparatide T33 N-term Van der Waals
abaloparatide K34 N-term Van der Waals
abaloparatide D113 N-term Van der Waals
abaloparatide I115 N-term Van der Waals
abaloparatide I115 N-term hydrophobic
abaloparatide I135 N-term Van der Waals
abaloparatide I135 N-term hydrophobic
abaloparatide Y136 N-term Van der Waals
abaloparatide Y136 N-term hydrophobic
abaloparatide D137 N-term polar (charge-assisted hydrogen bond)
abaloparatide F138 N-term Van der Waals
abaloparatide F138 N-term hydrophobic
abaloparatide R162 N-term polar (charge-assisted hydrogen bond)
abaloparatide N166 N-term Van der Waals
abaloparatide Y167 N-term polar (hydrogen bond with backbone)
abaloparatide Y167 N-term Van der Waals
abaloparatide S168 N-term Van der Waals
abaloparatide V171 N-term hydrophobic
abaloparatide V171 N-term Van der Waals
abaloparatide F184 1.36x36 TM1 Van der Waals
abaloparatide F184 1.36x36 TM1 hydrophobic
abaloparatide L187 1.39x39 TM1 Van der Waals
abaloparatide L187 1.39x39 TM1 hydrophobic
abaloparatide R233 2.60x60 TM2 Van der Waals
abaloparatide Y245 ECL1 Van der Waals
abaloparatide Y245 ECL1 hydrophobic
abaloparatide F288 3.36x36 TM3 hydrophobic
abaloparatide F288 3.36x36 TM3 Van der Waals
abaloparatide L289 3.37x37 TM3 Van der Waals
abaloparatide Y296 3.44x44 TM3 Van der Waals
abaloparatide D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
abaloparatide D353 45.52x52 ECL2 Van der Waals
abaloparatide L354 ECL2 Van der Waals
abaloparatide L354 ECL2 hydrophobic
abaloparatide S355 ECL2 Van der Waals
abaloparatide K360 5.36x37 TM5 Van der Waals
abaloparatide Q364 5.40x40 TM5 polar (hydrogen bond)
abaloparatide I367 5.43x43 TM5 Van der Waals
abaloparatide I367 5.43x43 TM5 hydrophobic
abaloparatide L368 5.44x44 TM5 Van der Waals
abaloparatide M425 6.57x57 TM6 Van der Waals
abaloparatide M425 6.57x57 TM6 polar (hydrogen bond with backbone)
abaloparatide T427 6.59x59 TM6 Van der Waals
abaloparatide Y429 ECL3 polar (hydrogen bond)
abaloparatide Y429 ECL3 Van der Waals
abaloparatide T430 ECL3 polar (hydrogen bond with backbone)
abaloparatide T430 ECL3 Van der Waals
abaloparatide W437 7.35x34 TM7 polar (hydrogen bond)
abaloparatide W437 7.35x34 TM7 Van der Waals
abaloparatide Q440 7.38x37 TM7 polar (hydrogen bond)
abaloparatide Q440 7.38x37 TM7 Van der Waals
abaloparatide M441 7.39x38 TM7 polar (hydrogen bond)
abaloparatide E444 7.42x41 TM7 polar (charge-assisted hydrogen bond)
abaloparatide M445 7.43x42 TM7 hydrophobic
abaloparatide M445 7.43x42 TM7 Van der Waals
abaloparatide N448 7.46x45 TM7 polar (hydrogen bond)
abaloparatide N448 7.46x45 TM7 Van der Waals

Ligands

abaloparatide

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x32 1.36x36 F184
1x35 1.39x39 L187
TM2
2x53 2.60x60 R233
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x52 6.57x57 M425
6x54 6.59x59 T427
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448