Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7Y36

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 5, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
teriparatide M32 N-term polar (hydrogen bond with backbone)
teriparatide M32 N-term Van der Waals
teriparatide T33 N-term polar (hydrogen bond with backbone)
teriparatide T33 N-term Van der Waals
teriparatide K34 N-term polar (charge-assisted hydrogen bond)
teriparatide Q37 N-term Van der Waals
teriparatide I38 N-term hydrophobic
teriparatide I38 N-term Van der Waals
teriparatide L41 N-term Van der Waals
teriparatide L41 N-term hydrophobic
teriparatide D113 N-term Van der Waals
teriparatide H114 N-term Van der Waals
teriparatide I115 N-term Van der Waals
teriparatide I115 N-term hydrophobic
teriparatide I135 N-term hydrophobic
teriparatide I135 N-term Van der Waals
teriparatide Y136 N-term Van der Waals
teriparatide D137 N-term polar (charge-assisted hydrogen bond)
teriparatide F138 N-term hydrophobic
teriparatide F138 N-term Van der Waals
teriparatide R162 N-term polar (charge-assisted hydrogen bond)
teriparatide A165 N-term Van der Waals
teriparatide A165 N-term polar (hydrogen bond with backbone)
teriparatide Y167 N-term aromatic (edge-to-face)
teriparatide Y167 N-term Van der Waals
teriparatide V171 N-term hydrophobic
teriparatide L174 N-term Van der Waals
teriparatide L174 N-term hydrophobic
teriparatide T175 N-term polar (hydrogen bond)
teriparatide T175 N-term Van der Waals
teriparatide E180 1.32x32 TM1 polar (charge-assisted hydrogen bond)
teriparatide F184 1.36x36 TM1 hydrophobic
teriparatide F184 1.36x36 TM1 Van der Waals
teriparatide Y195 1.47x47 TM1 polar (hydrogen bond)
teriparatide R233 2.60x60 TM2 Van der Waals
teriparatide Y245 2.72x72 TM2 hydrophobic
teriparatide Y245 2.72x72 TM2 Van der Waals
teriparatide F288 3.36x36 TM3 hydrophobic
teriparatide F288 3.36x36 TM3 Van der Waals
teriparatide L289 3.37x37 TM3 Van der Waals
teriparatide L289 3.37x37 TM3 hydrophobic
teriparatide L292 3.40x40 TM3 hydrophobic
teriparatide L292 3.40x40 TM3 Van der Waals
teriparatide Y296 3.44x44 TM3 Van der Waals
teriparatide D353 45.52x52 ECL2 Van der Waals
teriparatide D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
teriparatide L354 ECL2 Van der Waals
teriparatide L354 ECL2 hydrophobic
teriparatide S355 ECL2 polar (hydrogen bond with backbone)
teriparatide S355 ECL2 Van der Waals
teriparatide Q364 5.40x40 TM5 Van der Waals
teriparatide L368 5.44x44 TM5 Van der Waals
teriparatide F424 6.56x56 TM6 Van der Waals
teriparatide F424 6.56x56 TM6 polar (hydrogen bond with backbone)
teriparatide M425 ECL3 Van der Waals
teriparatide M425 ECL3 polar (hydrogen bond with backbone)
teriparatide T427 ECL3 polar (hydrogen bond with backbone)
teriparatide T427 ECL3 Van der Waals
teriparatide P428 ECL3 Van der Waals
teriparatide Y429 ECL3 hydrophobic
teriparatide Y429 ECL3 Van der Waals
teriparatide V432 ECL3 Van der Waals
teriparatide W437 7.35x34 TM7 polar (hydrogen bond)
teriparatide W437 7.35x34 TM7 Van der Waals
teriparatide Q440 7.38x37 TM7 polar (hydrogen bond)
teriparatide Q440 7.38x37 TM7 Van der Waals
teriparatide M441 7.39x38 TM7 hydrophobic
teriparatide M441 7.39x38 TM7 Van der Waals
teriparatide E444 7.42x41 TM7 Van der Waals
teriparatide M445 7.43x42 TM7 hydrophobic
teriparatide M445 7.43x42 TM7 Van der Waals
teriparatide N448 7.46x45 TM7 polar (hydrogen bond)
teriparatide N448 7.46x45 TM7 Van der Waals

Ligands

teriparatide

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x28 1.32x32 E180
1x32 1.36x36 F184
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x44 5.40x40 Q364
5x48 5.44x44 L368
TM6
6x51 6.56x56 F424
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448