PDB
7Y66
Resolution
2.9 Å
Released
March 1, 2023
Receptor
C5a1
Class
A
Species
Homo sapiens
Ligand
Function
BM213
Agonist
Reference
10.1038/S41422-023-00779-2

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
BM213 L92 2.60x60 TM2 hydrophobic
BM213 H100 ECL1 Van der Waals
BM213 I116 3.32x32 TM3 hydrophobic
BM213 L117 3.33x33 TM3 hydrophobic
BM213 M120 3.36x36 TM3 Van der Waals
BM213 R175 ECL2 polar (charge-charge)
BM213 R178 ECL2 hydrophobic
BM213 L187 ECL2 hydrophobic
BM213 C188 45.50x50 ECL2 Van der Waals
BM213 G189 45.51x51 ECL2 Van der Waals
BM213 V190 45.52x52 ECL2 polar (hydrogen bond with backbone)
BM213 D191 ECL2 Van der Waals
BM213 E199 5.35x36 TM5 polar (charge-charge)
BM213 R206 5.42x43 TM5 polar (charge-charge)
BM213 Y258 6.51x51 TM6 polar (hydrogen bond with backbone)
BM213 Y258 6.51x51 TM6 aromatic (pi-cation)
BM213 T261 6.54x54 TM6 Van der Waals
BM213 G262 6.55x55 TM6 Van der Waals
BM213 M265 6.58x58 TM6 hydrophobic
BM213 L268 6.61x61 TM6 Van der Waals
BM213 F275 7.28x27 TM7 Van der Waals
BM213 K279 7.32x31 TM7 Van der Waals
BM213 D282 7.35x34 TM7 polar (charge-charge)
BM213 C285 7.38x37 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 A K R ICL1ECL1 H H W P F ECL1ICL2 P I W C Q N F R ICL2ECL2 V V R E E Y F P P K V L C G V D Y S H ECL2ICL3 R A T R S ICL3ECL3 E P S ECL3N-term M D S F N Y T T P D Y G H Y D D K D T L D L N T P V D K T S N T L N-termC-term L P S L L R N V L T E E S V V R E S K S F T R S T V D T M A Q K T Q A V C-term R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G A G L A W I A C A V A W G L A L L L T I P S F L Y R D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F R K S Q G R L
Helix box plot — Download: PNG | SVG A N G L V G V L F V V A F I V L A L I D 1 L N L A V A D F L S C L A L P I L F T S 2 T A L L L I S A Y M N L L I L S P L I S 3 A W I A C A V A W G L A L L L T I P S 4 Y C I T L T L L P W L F G L V L R V I A V 5 V A V V A S F F I F W L P Y Q V T G I M 6 I P N I C C N I Y A F S V C L S D L K 7

GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM2
2x60 2.60x60 L92
TM3
3x32 3.32x32 I116
3x33 3.33x33 L117
3x36 3.36x36 M120
ECL2
45x50 45.50x50 C188
45x51 45.51x51 G189
45x52 45.52x52 V190
TM5
5x36 5.35x36 E199
5x43 5.42x43 R206
TM6
6x51 6.51x51 Y258
6x54 6.54x54 T261
6x55 6.55x55 G262
6x58 6.58x58 M265
6x61 6.61x61 L268
TM7
7x27 7.28x27 F275
7x31 7.32x31 K279
7x34 7.35x34 D282
7x37 7.38x37 C285