Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YAE

SPECIES

Homo sapiens

RESOLUTION

3.370

PREFERRED CHAIN

E

REFERENCE

10.1038/S41467-023-36673-Z

PUBLICATION DATE

April 19, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octreotide D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Octreotide Q126 3.36x36 TM3 polar (hydrogen bond)
Octreotide T194 45.51x51 ECL2 Van der Waals
Octreotide I195 45.52x52 ECL2 hydrophobic
Octreotide I195 45.52x52 ECL2 Van der Waals
Octreotide W204 5.34x35 TM5 Van der Waals
Octreotide W204 5.34x35 TM5 hydrophobic
Octreotide Y205 5.35x36 TM5 hydrophobic
Octreotide Y205 5.35x36 TM5 Van der Waals
Octreotide F208 5.38x39 TM5 Van der Waals
Octreotide F208 5.38x39 TM5 hydrophobic
Octreotide F272 6.51x51 TM6 Van der Waals
Octreotide F272 6.51x51 TM6 hydrophobic
Octreotide N276 6.55x55 TM6 Van der Waals
Octreotide S279 6.58x58 TM6 polar (hydrogen bond)
Octreotide S279 6.58x58 TM6 polar (hydrogen bond)
Octreotide P286 ECL3 Van der Waals
Octreotide P286 ECL3 hydrophobic
Octreotide K291 7.32x31 TM7 Van der Waals
Octreotide F294 7.35x34 TM7 hydrophobic
Octreotide F294 7.35x34 TM7 Van der Waals
Octreotide Y302 7.43x42 TM7 polar (hydrogen bond)

Ligands

Octreotide

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x35 5.34x35 W204
5x36 5.35x36 Y205
5x39 5.38x39 F208
TM6
6x51 6.51x51 F272
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x31 7.32x31 K291
7x34 7.35x34 F294
7x42 7.43x42 Y302