PDB
7YFC
Resolution
3.0 Å
Released
Oct. 25, 2023
Receptor
H4
Class
A
Species
Homo sapiens
Ligand
histamine
Function
Agonist
Reference
10.1038/S41467-023-42260-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
histamine D94 3.32x32 TM3 polar (charge-assisted hydrogen bond)
histamine Y95 3.33x33 TM3 Van der Waals
histamine Y95 3.33x33 TM3 aromatic (face-to-face)
histamine C98 3.36x36 TM3 Van der Waals
histamine E182 5.46x461 TM5 polar (charge-assisted hydrogen bond)
histamine Y319 6.51x51 TM6 Van der Waals
histamine F344 7.39x38 TM7 hydrophobic
histamine F344 7.39x38 TM7 Van der Waals
histamine Q347 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K N L R ICL1ECL1 F E W D F ECL1ICL2 A V S Y R T Q H T ICL2ECL2 D E G S E C E P G F F S ECL2ICL3 H P G L T A V S S N I C G H S F R G R L S S R R S L S A S T E V P A S F H S E R Q R R K S S L M F S S R T K M N S N T I A S K M G S F S Q S D S V A L H Q R E ICL3ECL3 S S A T G P K ECL3N-term M P D T N S T I N L N-termC-term K K Q P L P S Q H S R S V S S C-term S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L S R C Q S H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F L K F Q K A I F C I
Helix box plot — Download: PNG | SVG A N G L M I A F A V L S M F F A L T V R 1 L N L A I S D F F V G I V S I P L Y I P H 2 L V I N Y V S A T C L L Y D T T L W F V 3 I V T L M V A V W V L A F L V N G P M 4 N F Y A V L I V P I V F E L F S T I A L I 5 A I L L G V F A V C W A P Y S L F T I V 6 L P N V F S N F W Q L W F A I R Y W V 7

GPCRdb(A)
GPCRdb(A)
H4 receptor
TM3
3x32 3.32x32 D94
3x33 3.33x33 Y95
3x36 3.36x36 C98
TM5
5x461 5.46x461 E182
TM6
6x51 6.51x51 Y319
TM7
7x38 7.39x38 F344
7x41 7.42x41 Q347