PDB
7YJ4
Resolution
3.2 Å
Released
March 1, 2023
Receptor
RXFP4
Class
A
Species
Homo sapiens
Ligands
Function
INSL5 (chain B)
Agonist
INSL5 (chain A)
Agonist
Reference
10.1038/S41467-023-36182-Z
INSL5 (chain B) INSL5 (chain A)

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Ligand Amino Acid Generic Number Segment Interaction Type
INSL5 (chain B) W97 2.60x60 TM2 Van der Waals
INSL5 (chain B) E100 2.63x63 TM2 polar (charge-charge)
INSL5 (chain B) E100 2.63x63 TM2 polar (hydrogen bond)
INSL5 (chain B) D104 ECL1 polar (hydrogen bond)
INSL5 (chain B) D104 ECL1 polar (charge-charge)
INSL5 (chain B) F105 ECL1 hydrophobic
INSL5 (chain B) F105 ECL1 aromatic (edge-to-face)
INSL5 (chain B) W107 23.50x50 ECL1 Van der Waals
INSL5 (chain B) L118 3.29x29 TM3 hydrophobic
INSL5 (chain B) T121 3.32x32 TM3 Van der Waals
INSL5 (chain B) V122 3.33x33 TM3 Van der Waals
INSL5 (chain B) V125 3.36x36 TM3 Van der Waals
INSL5 (chain B) C186 ECL2 Van der Waals
INSL5 (chain B) L190 ECL2 hydrophobic
INSL5 (chain B) L192 45.51x51 ECL2 Van der Waals
INSL5 (chain B) Q205 5.39x40 TM5 Van der Waals
INSL5 (chain B) R208 5.42x43 TM5 polar (charge-charge)
INSL5 (chain B) R208 5.42x43 TM5 aromatic (pi-cation)
INSL5 (chain B) R208 5.42x43 TM5 polar (hydrogen bond)
INSL5 (chain A) V277 ECL3 Van der Waals
INSL5 (chain A) W279 ECL3 hydrophobic
INSL5 (chain B) Q287 7.31x30 TM7 polar (hydrogen bond with backbone)
INSL5 (chain B) T288 7.32x31 TM7 hydrophobic
INSL5 (chain B) F291 7.35x34 TM7 Van der Waals
INSL5 (chain B) T295 7.39x38 TM7 hydrophobic
INSL5 (chain B) H299 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R A R A P ICL1ECL1 F H W P F ECL1ICL2 A A G P G T H L ICL2ECL2 V E G E V C G V R L C L L R F P S R ECL2ICL3 Q R ICL3ECL3 V P W N S ECL3N-term M P T L N T S A S P P T F F W A N A S G G S V L S A D D A P M P V K N-termC-term L R L R L W P Q G G G W V Q Q V A L K Q V G R R W V A S N P R E S R P S T L L T N L D R G T P G C-term F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S N C G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M S L F W A R I A T L A V W A A A A L V T V P T A V F G Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E L A G P R Q A T F R D
Helix box plot — Download: PNG | SVG L N G L L G I A G V L G Y A L A V M L R 1 F N L A L A D L G L A L T L P F W A A E 2 A T I L F I S A Y V N L V T A T L V M K 3 A R I A T L A V W A A A A L V T V P T 4 Y S T T I V G L P V M F A L V V R Q L Q Y 5 R I L V A S F F L C W F P N H V V T L W 6 V P N L C S N S H A L C T T V P F V Y 7

GPCRdb(A)
GPCRdb(A)
RXFP4
TM2
2x60 2.60x60 W97
2x63 2.63x63 E100
ECL1
23x50 23.50x50 W107
TM3
3x29 3.29x29 L118
3x32 3.32x32 T121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x51 45.51x51 L192
TM5
5x40 5.39x40 Q205
5x43 5.42x43 R208
TM7
7x30 7.31x30 Q287
7x31 7.32x31 T288
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 H299