Ligands
Function
Agonist
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| INSL5 (chain B) | W97 | 2.60x60 | TM2 | Van der Waals |
| INSL5 (chain B) | W97 | 2.60x60 | TM2 | hydrophobic |
| INSL5 (chain B) | E100 | 2.63x63 | TM2 | polar (charge-assisted hydrogen bond) |
| INSL5 (chain B) | D104 | ECL1 | polar (charge-assisted hydrogen bond) | |
| INSL5 (chain B) | F105 | ECL1 | Van der Waals | |
| INSL5 (chain B) | F105 | ECL1 | aromatic (edge-to-face) | |
| INSL5 (chain B) | L118 | 3.29x29 | TM3 | Van der Waals |
| INSL5 (chain B) | T121 | 3.32x32 | TM3 | polar (hydrogen bond) |
| INSL5 (chain B) | T121 | 3.32x32 | TM3 | Van der Waals |
| INSL5 (chain B) | C186 | ECL2 | Van der Waals | |
| INSL5 (chain B) | L190 | ECL2 | Van der Waals | |
| INSL5 (chain B) | Q205 | 5.39x40 | TM5 | Van der Waals |
| INSL5 (chain B) | Q205 | 5.39x40 | TM5 | polar (hydrogen bond) |
| INSL5 (chain B) | R208 | 5.42x43 | TM5 | polar (charge-assisted hydrogen bond) |
| INSL5 (chain A) | V277 | ECL3 | Van der Waals | |
| INSL5 (chain A) | W279 | ECL3 | hydrophobic | |
| INSL5 (chain A) | W279 | ECL3 | Van der Waals | |
| INSL5 (chain B) | Q287 | 7.31x30 | TM7 | polar (hydrogen bond with backbone) |
| INSL5 (chain B) | Q287 | 7.31x30 | TM7 | Van der Waals |
| INSL5 (chain B) | T288 | 7.32x31 | TM7 | Van der Waals |
| INSL5 (chain B) | F291 | 7.35x34 | TM7 | hydrophobic |
| INSL5 (chain B) | F291 | 7.35x34 | TM7 | Van der Waals |
| INSL5 (chain B) | H299 | 7.43x42 | TM7 | Van der Waals |
, 'snake_7YJ4.png', {scale: 3});){kind=link}
, 'helixbox7YJ4.png', {scale: 3});){kind=link}
|
GPCRdb(A)
|
GPCRdb(A)
|
RXFP4
|
|---|---|---|
| TM2 | ||
| 2x60 | 2.60x60 | W97 |
| 2x63 | 2.63x63 | E100 |
| TM3 | ||
| 3x29 | 3.29x29 | L118 |
| 3x32 | 3.32x32 | T121 |
| TM5 | ||
| 5x40 | 5.39x40 | Q205 |
| 5x43 | 5.42x43 | R208 |
| TM7 | ||
| 7x30 | 7.31x30 | Q287 |
| 7x31 | 7.32x31 | T288 |
| 7x34 | 7.35x34 | F291 |
| 7x42 | 7.43x42 | H299 |