PDB
7YK7
Resolution
2.8 Å
Released
March 1, 2023
Receptor
RXFP4
Class
A
Species
Homo sapiens
Ligand
Function
DC591053
Agonist
Reference
10.1038/S41467-023-36182-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
DC591053 W97 2.60x60 TM2 hydrophobic
DC591053 F105 ECL1 Van der Waals
DC591053 L118 3.29x29 TM3 hydrophobic
DC591053 T121 3.32x32 TM3 Van der Waals
DC591053 L190 ECL2 hydrophobic
DC591053 C191 45.50x50 ECL2 Van der Waals
DC591053 L192 45.51x51 ECL2 Van der Waals
DC591053 L193 45.52x52 ECL2 Van der Waals
DC591053 R194 ECL2 aromatic (pi-cation)
DC591053 Y204 5.38x39 TM5 Van der Waals
DC591053 Q205 5.39x40 TM5 Van der Waals
DC591053 R208 5.42x43 TM5 Van der Waals
DC591053 Q287 7.31x30 TM7 Van der Waals
DC591053 F291 7.35x34 TM7 hydrophobic
DC591053 T295 7.39x38 TM7 polar (hydrogen bond)
DC591053 H299 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R A R A P ICL1ECL1 F H W P F ECL1ICL2 A A G P G T H L ICL2ECL2 V E G E V C G V R L C L L R F P S R ECL2ICL3 Q R ICL3ECL3 V P W N S ECL3N-term M P T L N T S A S P P T F F W A N A S G G S V L S A D D A P M P V K N-termC-term L R L R L W P Q G G G W V Q Q V A L K Q V G R R W V A S N P R E S R P S T L L T N L D R G T P G C-term F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S N C G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M S L F W A R I A T L A V W A A A A L V T V P T A V F G Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E L A G P R Q A T F R D
Helix box plot — Download: PNG | SVG L N G L L G I A G V L G Y A L A V M L R 1 F N L A L A D L G L A L T L P F W A A E 2 A T I L F I S A Y V N L V T A T L V M K 3 A R I A T L A V W A A A A L V T V P T 4 Y S T T I V G L P V M F A L V V R Q L Q Y 5 R I L V A S F F L C W F P N H V V T L W 6 V P N L C S N S H A L C T T V P F V Y 7

GPCRdb(A)
GPCRdb(A)
RXFP4
TM2
2x60 2.60x60 W97
TM3
3x29 3.29x29 L118
3x32 3.32x32 T121
ECL2
45x50 45.50x50 C191
45x51 45.51x51 L192
45x52 45.52x52 L193
TM5
5x39 5.38x39 Y204
5x40 5.39x40 Q205
5x43 5.42x43 R208
TM7
7x30 7.31x30 Q287
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 H299